Nature Communications (Mar 2019)
Rapid active zone remodeling consolidates presynaptic potentiation
- Mathias A. Böhme,
- Anthony W. McCarthy,
- Andreas T. Grasskamp,
- Christine B. Beuschel,
- Pragya Goel,
- Meida Jusyte,
- Desiree Laber,
- Sheng Huang,
- Ulises Rey,
- Astrid G. Petzoldt,
- Martin Lehmann,
- Fabian Göttfert,
- Pejmun Haghighi,
- Stefan W. Hell,
- David Owald,
- Dion Dickman,
- Stephan J. Sigrist,
- Alexander M. Walter
Affiliations
- Mathias A. Böhme
- Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
- Anthony W. McCarthy
- Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
- Andreas T. Grasskamp
- Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
- Christine B. Beuschel
- NeuroCure Cluster of Excellence, Charité Universitätsmedizin
- Pragya Goel
- Department of Neurobiology, University of Southern California
- Meida Jusyte
- Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
- Desiree Laber
- Institut für Neurophysiologie, Charité Universitätsmedizin
- Sheng Huang
- Institute for Biology/Genetics, Freie Universität Berlin
- Ulises Rey
- Institute for Biology/Genetics, Freie Universität Berlin
- Astrid G. Petzoldt
- Institute for Biology/Genetics, Freie Universität Berlin
- Martin Lehmann
- Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
- Fabian Göttfert
- Department of Nanobiophotonics, Max Planck Institute for Biophysical Chemistry
- Pejmun Haghighi
- Buck Institute for Research on Aging
- Stefan W. Hell
- Department of Nanobiophotonics, Max Planck Institute for Biophysical Chemistry
- David Owald
- Institut für Neurophysiologie, Charité Universitätsmedizin
- Dion Dickman
- Department of Neurobiology, University of Southern California
- Stephan J. Sigrist
- NeuroCure Cluster of Excellence, Charité Universitätsmedizin
- Alexander M. Walter
- Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
- DOI
- https://doi.org/10.1038/s41467-019-08977-6
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Synaptic plasticity ensures functionality during perturbations and enables memory formation. Here, the authors describe homeostatic functional and nano-modular active zone modifications for immediate and long-lasting enhancement of neurotransmitter release, and identify Unc13 as a presynaptic molecular target for homeostatic potentiation and learning.
