Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer

Myoung-Hee Kang; Hyunji Choi; Masanobu Oshima; Jae-Ho Cheong; Seokho Kim; Jung Hoon Lee; Young Soo Park; Hueng-Sik Choi; Mi-Na Kweon; Chan-Gi Pack; Ju-Seog Lee; Gordon B. Mills; Seung-Jae Myung; Yun-Yong Park

doi:10.1038/s41467-018-04244-2

Nature Communications (May 2018)

Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer

Myoung-Hee Kang,
Hyunji Choi,
Masanobu Oshima,
Jae-Ho Cheong,
Seokho Kim,
Jung Hoon Lee,
Young Soo Park,
Hueng-Sik Choi,
Mi-Na Kweon,
Chan-Gi Pack,
Ju-Seog Lee,
Gordon B. Mills,
Seung-Jae Myung,
Yun-Yong Park

Affiliations

Myoung-Hee Kang: ASAN Institute for Life Sciences, ASAN Medical Center, University of Ulsan College of Medicine
Hyunji Choi: Department of Biological Sciences, Dong-A University
Masanobu Oshima: Division of Genetics, Cancer Research Institute, Kanazawa University
Jae-Ho Cheong: Department of Surgery, Yonsei University College of Medicine
Seokho Kim: Aging Research Institute, Korea Research Institute of Bioscience and Biotechnology
Jung Hoon Lee: Department of Gastroenterology, University of Ulsan College of Medicine
Young Soo Park: Department of Pathology, University of Ulsan College of Medicine
Hueng-Sik Choi: National Creative Research Initiatives Center for Nuclear Receptor Signals and Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University
Mi-Na Kweon: Department of Convergence Medicine, University of Ulsan College of Medicine
Chan-Gi Pack: ASAN Institute for Life Sciences, ASAN Medical Center, University of Ulsan College of Medicine
Ju-Seog Lee: Department of Systems Biology, MD Anderson Cancer Center
Gordon B. Mills: Department of Systems Biology, MD Anderson Cancer Center
Seung-Jae Myung: ASAN Institute for Life Sciences, ASAN Medical Center, University of Ulsan College of Medicine
Yun-Yong Park: ASAN Institute for Life Sciences, ASAN Medical Center, University of Ulsan College of Medicine

DOI: https://doi.org/10.1038/s41467-018-04244-2
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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Very little is known regarding the molecular mechanisms involved in gastric cancer development. Here the authors show estrogen-related receptor gamma (ESRRG) is a tumor suppressor in gastric cancer and suggest the mechanism of this tumor suppression function involves the inhibition of Wnt signaling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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