Combined surgery for neovascular angle-closure glaucoma secondary to proliferative diabetic retinopathy

Abstract

AIM:To explore the efficacy and safety of combined surgery for neovascular angle-closure glaucoma secondary to proliferative diabetic retinopathy(PDR). METHODS:A prospective nonrandomized clinical study was performed. All enrolled patients were initially treated with intravitreal injection of ranibizumab at the dose of 0.5mg(0.05mL). After new vessels(NV)on the iris and the angle of anterior chamber regressed completely, all patients received phacoemulsification(PHACO), intraocular lens implantation(IOL), trabeculectomy(TRAB), pars plana vitrectomy(PPV)and endophotocoagulation(EPC). The changes of best corrected visual acuity(BCVA), intraocular pressure(IOP), NV and complications were observed, and followed up for 6mo. RESULTS:Nineteen eyes of 19 patients with neovascular glaucoma(NVG)were involved in this study. After followed up for 6mo, postoperative BCVA of all was improved. Mean IOP was decreased significantly(PCONCLUSION:Combined surgery of intravitreal injection of ranibizumab as adjunctive treatment for PHACO+IOL+TRAB+PPV+EPC could be safe and effect for neovascular angle-closure glaucoma secondary to PDR.

Keywords

• secondary neovascular angleclosure glaucoma
• intravitreal ranibizumab injection
• phacoemulsification
• intraocular lens implantation
• trabeculectomy
• pars plana vitrectomy
• endophotocoagulation