PLoS ONE (Jan 2021)

Prevalence of migraine in adults with celiac disease: A case control cross-sectional study.

  • Mohammad M Fanaeian,
  • Nazanin Alibeik,
  • Azita Ganji,
  • Hafez Fakheri,
  • Golnaz Ekhlasi,
  • Bijan Shahbazkhani

DOI
https://doi.org/10.1371/journal.pone.0259502
Journal volume & issue
Vol. 16, no. 11
p. e0259502

Abstract

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AimCeliac disease (CD) is an immune-mediated disorder with various manifestations. The aim of this study was to evaluate the prevalence of gastrointestinal (GI) and extra-intestinal symptoms of celiac patients, especially migraine, and compare it with healthy individuals.MethodsWe compared 1000 celiac subjects (CS) registered at our celiac center with the control group for headache-based on International Classification of Headache Disorders, third edition criteria and their GI symptoms. Besides, CS with migraine and non-migrainous headache were compared in terms of GI symptoms and accompanied conditions.ResultsHeadache was more common in CS than controls (34% vs 27% respectively, P valueConclusionHeadache especially migraine is more prevalent in CS than healthy controls. In addition, abdominal pain, diarrhea, and constipation are more common in CS with migraine than in CS with non-migrainous headaches. Therefore, evaluation of CD in patients with migraine and these simultaneous GI symptoms seems reasonable.