Neural Regeneration Research (Jan 2015)
Peripheral nerve repair: a hot spot analysis on treatment methods from 2010 to 2014
- Guang-yao Liu,
- Yan Jin,
- Qiao Zhang,
- Rui Li
Affiliations
- Guang-yao Liu
- Yan Jin
- Qiao Zhang
- Rui Li
- DOI
- https://doi.org/10.4103/1673-5374.158368
- Journal volume & issue
-
Vol. 10,
no. 6
pp. 996 – 1002
Abstract
Therapeutic strategies for neurological deficits and for promoting nerve regeneration after peripheral nerve injuries have received much focus in clinical research. Advances in basic research in recent years have increased our understanding of the anatomy of peripheral nerves and the importance of the microenvironment. Various new intervention methods have been developed, but with varying effectiveness. In the present study, we selected 911 papers on different repair methods for peripheral nerve injury from the Web of Science and indexed in the Science Citation Index from 2010 to 2014. We quantitatively examine new repair methods and strategies using bibliometrics, and we discuss the present state of knowledge and the problems and prospects of various repair methods, including nerve transfer, neural transplantation, tissue engineering and genetic engineering. Our findings should help in the study and development of repair methods for peripheral nerve injury.
Keywords
- microtubule
- axon
- kinesin-5
- Eg5
- regeneration
- monastrol
- molecular motor protein
- aging
- neurodegenerative disorders
- telomere shortening
- MSCs
- cellular therapy
- traumatic brain injury
- spinal cord injuries
- dual diagnosis
- diagnosis
- complications
- rehabilitation
- post-concussion syndrome
- brain concussion
- blood brain barrier
- phage display
- peptide library
- nanocarrier
- targeting
- Schwann cells
- neurite outgrowth
- neuromuscular junction (NMJ)
- multiple sclerosis
- TGF-β/BMP-7/Smad signaling
- myogenic differentiation
- Trf3
- tumor suppression
- nerve regeneration
- bone marrow mesenchymal stem cells
- cerebral ischemia
- tail vein injection
- middle cerebral artery occlusion
- cell therapy
- neuroprotection
- nerve regeneration
- brain injury
- neuroimaging
- ferumoxytol
- superparamagnetic iron oxide particles
- human adipose-derived stem cells
- middle cerebral artery occlusion
- intracerebral injection
- magnetic resonance imaging
- enhanced susceptibility-weighted angiography image
- modified neurological severity scores
- rats
- Prussian blue staining
- neural regeneration
- neural regeneration
- non-invasive brain stimulation
- transcranial magnetic stimulation
- neurotrophic factor
- brain-derived neurotrophic factor
- neuroplasticity
- hippocampus
- aging
- cognitive function
- nerve regeneration
- curcumin
- neurons
- HIV-1 gp120 V3 loop
- plasticity
- HIV-associated neurocognitive disorders
- output/input curve
- long-term potentiation
- excitatory postsynaptic potential
- paired-pulse facilitation
- Ca 2+
- synaptosome
- NSFC grants
- neural regeneration
- nerve regeneration
- brain injury
- hydrogen sulfide
- cerebral ischemia/reperfusion injury
- P2X 7 receptor
- 2
- 3
- 5-triphenyl-2H-tetrazolium chloride staining
- animal model
- protection
- sodium hydrosulfide
- immunofluorescence
- middle cerebral artery occlusion
- NSFC grant
- neural regeneration
- nerve regeneration
- γ-aminobutyric acid
- glial fibrillary acidic protein
- glutamic acid decarboxylase
- neurotoxicity
- weaning
- organ index
- cerebrum
- cortex
- glutamate
- neural regeneration
- p53 tumor suppressor gene family
- cerebral ischemia/reperfusion
- pyramidal neurons
- CA1 region
- delayed neuronal death
- immunohistochemistry
- western blotting
- neural regeneration
- nerve regeneration
- spinal cord injury
- rapamycin
- Wnt/β-catenin signaling pathway
- apoptosis
- caspase-3
- brain-derived neurotrophic factor
- neuroprotection
- loss of neurons
- NSFC grants
- neural regeneration
- nerve regeneration
- spinal cord injury
- hydrogen-rich saline
- reactive oxygen species
- physiological saline
- oxidative stress
- Basso
- Beattie and Bresnahan score
- malondialdehyde
- superoxide dismutase
- calcitonin gene-related peptide
- caspase-3
- neural regeneration
- nerve regeneration
- peripheral nerve injury
- rabbits
- sciatic nerve injury
- autologous nerve repair
- polylactic glycolic acid conduit
- extracellular matrix gel
- grafting
- stress relaxation
- creep
- viscoelasticity
- histomorphology
- electrophysiology
- neural regeneration
- nerve regeneration
- peripheral nerve injury
- pain sense model
- dorsal root ganglion
- primary sensory neuron
- glycosylated membrane protein
- sialic acid
- cell electrophoresis
- electrophoresis velocity
- heat-hyperalgesia behavior
- hyperalgesia
- neuraminidase
- neural regeneration
- N-propionylmannosamine
- sialic acid
- glycoengineering
- sciatic nerve
- peripheral nerve
- branching
- arborisation
- Thy1-YFP mouse
- nerve regeneration
- stem cells
- optic nerve
- optic neuropathy
- ophthalmology
- bone marrow-derived stem cells
- blindness
- visual loss
- nerve regeneration
- gustation
- cytokeratin
- tongue epithelium
- immunohistochemistry
- taste bud
- trigeminal nerve disorder
- NSFC grants
- neural regeneration
- nerve regeneration
- peripheral nerve injury
- nerve repair
- neural transplantation
- nerve transfer
- tissue engineering
- genetic engineering
- bibliometrics
- Web of Science
- neural regeneration