Nature Communications (Aug 2020)
A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction
- Monir Ejemel,
- Qi Li,
- Shurong Hou,
- Zachary A. Schiller,
- Julia A. Tree,
- Aaron Wallace,
- Alla Amcheslavsky,
- Nese Kurt Yilmaz,
- Karen R. Buttigieg,
- Michael J. Elmore,
- Kerry Godwin,
- Naomi Coombes,
- Jacqueline R. Toomey,
- Ryan Schneider,
- Anudeep S. Ramchetty,
- Brianna J. Close,
- Da-Yuan Chen,
- Hasahn L. Conway,
- Mohsan Saeed,
- Chandrashekar Ganesa,
- Miles W. Carroll,
- Lisa A. Cavacini,
- Mark S. Klempner,
- Celia A. Schiffer,
- Yang Wang
Affiliations
- Monir Ejemel
- MassBiologics of the University of Massachusetts Medical School
- Qi Li
- MassBiologics of the University of Massachusetts Medical School
- Shurong Hou
- Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School
- Zachary A. Schiller
- MassBiologics of the University of Massachusetts Medical School
- Julia A. Tree
- National Infection Service, Public Health England, Porton Down
- Aaron Wallace
- MassBiologics of the University of Massachusetts Medical School
- Alla Amcheslavsky
- MassBiologics of the University of Massachusetts Medical School
- Nese Kurt Yilmaz
- Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School
- Karen R. Buttigieg
- National Infection Service, Public Health England, Porton Down
- Michael J. Elmore
- National Infection Service, Public Health England, Porton Down
- Kerry Godwin
- National Infection Service, Public Health England, Porton Down
- Naomi Coombes
- National Infection Service, Public Health England, Porton Down
- Jacqueline R. Toomey
- MassBiologics of the University of Massachusetts Medical School
- Ryan Schneider
- MassBiologics of the University of Massachusetts Medical School
- Anudeep S. Ramchetty
- MassBiologics of the University of Massachusetts Medical School
- Brianna J. Close
- National Emerging Infectious Diseases Laboratories, Boston University
- Da-Yuan Chen
- National Emerging Infectious Diseases Laboratories, Boston University
- Hasahn L. Conway
- National Emerging Infectious Diseases Laboratories, Boston University
- Mohsan Saeed
- National Emerging Infectious Diseases Laboratories, Boston University
- Chandrashekar Ganesa
- MassBiologics of the University of Massachusetts Medical School
- Miles W. Carroll
- National Infection Service, Public Health England, Porton Down
- Lisa A. Cavacini
- MassBiologics of the University of Massachusetts Medical School
- Mark S. Klempner
- MassBiologics of the University of Massachusetts Medical School
- Celia A. Schiffer
- Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School
- Yang Wang
- MassBiologics of the University of Massachusetts Medical School
- DOI
- https://doi.org/10.1038/s41467-020-18058-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 9
Abstract
Here, Ejemel et al. report the identification and characterization of a cross-neutralizing human IgA monoclonal antibody, named MAb362, that binds the receptor-binding domain of SARS-CoV-2 Spike, blocking its interaction with the ACE2 host receptor.
