Мonocyte Chemoattractant Protein Levels in Patients with Primary Hypothyroidism

Abstract

Objective of the research — to study the content of monocyte chemoattractant protein‑1 (MCP‑1) in the urine of patients with primary hypothyroidism. Materials and methods. 141 patients with overt hypothyroidism have been examined. Among them, 71 patients had postoperative hypothyroidism, 70 — hypothyroidism on the background of autoimmune thyroiditis (AIT). Patients were divided: into I A group consisted of 35 patients with hypothyroidism following AIT without obesity; I B group — 35 patients suffering from AIT with hypothyroidism and obesity; II A group — 34 patients with postoperative hypothyroidism without obesity; II B group — patients with postoperative hypothyroidism and obesity. Results. The surveyed patients had significant increase of MHP‑1 levels in all groups. During correlation analysis, we have established a direct correlation between levels of MHP‑1 and thyroid-stimulating hormone, as well as creatinine levels in the blood and the reverse correlation of medium strength between glomerular filtration rate and concentration of MHP‑1, with the highest severity in the uncompensated hypothyroidism on the background of AIT with obesity. Conclusions. Identified correlations indicate that the level of MHP‑1 to a certain extent reflects renal function and can be used as a complement to traditional methods of examination of patients.

Keywords

• hypothyroidism
• thyroid hormones
• monocyte chemoattractant protein‑1.