EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming

Abstract

T box transcription factor Eomesodermin (EOMES) is induced when naïve T cells are converted to innate memory T cells in response to cytokines. Here the authors show that EOMES is recruited to RUNX3-bound enhancers and interacts with BRG1 during innate memory T cell formation.