BRCA1GENE EXPRESSION IN ENDOCRINE TUMORS OF THE GASTROINTESTINAL TRACT

I. G. Gafton; Е. N. Imyanitov; V. V. Semiglasov; D. Е. Matsko; G. I. Gafton; Yu. V. Semiletova; А. G. Ievleva; А. Е. Mikhnin; V. G. Lemekhov

Сибирский онкологический журнал (Feb 2016)

BRCA1GENE EXPRESSION IN ENDOCRINE TUMORS OF THE GASTROINTESTINAL TRACT

I. G. Gafton,
Е. N. Imyanitov,
V. V. Semiglasov,
D. Е. Matsko,
G. I. Gafton,
Yu. V. Semiletova,
А. G. Ievleva,
А. Е. Mikhnin,
V. G. Lemekhov

Affiliations

I. G. Gafton: N.N. Petrov Research Institute of Oncology, St.-Petersburg I.P. Pavlov State Medical University, St.-Petersburg
Е. N. Imyanitov: I.I. Mechnikov State Medical University, St.-Petersburg
V. V. Semiglasov: N.N. Petrov Research Institute of Oncology, St.-Petersburg I.P. Pavlov State Medical University, St.-Petersburg
D. Е. Matsko: N.N. Petrov Research Institute of Oncology, St.-Petersburg
G. I. Gafton: N.N. Petrov Research Institute of Oncology, St.-Petersburg
Yu. V. Semiletova: N.N. Petrov Research Institute of Oncology, St.-Petersburg I.I. Mechnikov State Medical University, St.-Petersburg
А. G. Ievleva: N.N. Petrov Research Institute of Oncology, St.-Petersburg
А. Е. Mikhnin: N.N. Petrov Research Institute of Oncology, St.-Petersburg I.I. Mechnikov State Medical University, St.-Petersburg
V. G. Lemekhov: N.N. Petrov Research Institute of Oncology, St.-Petersburg I.I. Mechnikov State Medical University, St.-Petersburg

Journal volume & issue: Vol. 0, no. 4
pp. 11 – 15

Abstract

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Results of molecular genetic study of BRCA1gene expression in patients with endocrine tumors of the gastrointestinal tract were presented. Based on the analysis of survival rates in patients with endocrine tumors of the gastrointestinal tract, the BRCA1expression level was suggested can be used as a prognostic criterion and as a factor determining the advisability of administration of platinum-based drugs. It was found that the more aggressive neuroendocrine tumors had the lower BRCA1expression. Therefore, administration of platinumcontaining chemotherapy is unlikely to offer any benefit for these patients.

Published in Сибирский онкологический журнал

ISSN: 1814-4861 (Print); 2312-3168 (Online)
Publisher: Russian Academy of Sciences, Tomsk National Research Medical Center
Country of publisher: Russian Federation
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://www.siboncoj.ru/jour

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