Immune reconstitution inflammatory syndrome‐associated lymphoma: A retrospective Brazilian cohort

Juliano Cordova Vargas; Karin Zattar Cecyn; Mariana deOliveira Marques; Juliana Pereira; Walter M. Tobias Braga; Nelson Hamerschlak; Jacques Tabacof; Caina D. deLiz; André Abdo; Paulo Roberto Abrão Ferreira; Gisele W. Braga Colleoni; Otavio C. G. Baiocchi

doi:10.1002/jha2.835

eJHaem (Feb 2024)

Immune reconstitution inflammatory syndrome‐associated lymphoma: A retrospective Brazilian cohort

Juliano Cordova Vargas,
Karin Zattar Cecyn,
Mariana deOliveira Marques,
Juliana Pereira,
Walter M. Tobias Braga,
Nelson Hamerschlak,
Jacques Tabacof,
Caina D. deLiz,
André Abdo,
Paulo Roberto Abrão Ferreira,
Gisele W. Braga Colleoni,
Otavio C. G. Baiocchi

Affiliations

Juliano Cordova Vargas: Department of Clinical and Experimental Oncology Federal University of São Paulo São Paulo SP Brazil
Karin Zattar Cecyn: Department of Clinical and Experimental Oncology Federal University of São Paulo São Paulo SP Brazil
Mariana deOliveira Marques: Department of Clinical and Experimental Oncology Federal University of São Paulo São Paulo SP Brazil
Juliana Pereira: Department of Clinical and Hematology São Paulo State Cancer Institute University of São Paulo São Paulo SP Brazil
Walter M. Tobias Braga: Department of Hematology Emílio Ribas Institute of Infectious Diseases São Paulo SP Brazil
Nelson Hamerschlak: Department of Hematology Américas Oncologia e Hematologia São Paulo SP Brazil
Jacques Tabacof: Centro Paulista de Oncologia São Paulo SP Brazil
Caina D. deLiz: Department of Hematology Hospital Sírio Libanês São Paulo SP Brazil
André Abdo: Department of Hematology Hospital Alemão Oswaldo Cruz São Paulo SP Brazil
Paulo Roberto Abrão Ferreira: Division of Infectious Disease Escola Paulista de Medicina Federal University of São Paulo São Paulo SP Brazil
Gisele W. Braga Colleoni: Department of Clinical and Experimental Oncology Federal University of São Paulo São Paulo SP Brazil
Otavio C. G. Baiocchi: Department of Clinical and Experimental Oncology Federal University of São Paulo São Paulo SP Brazil

DOI: https://doi.org/10.1002/jha2.835
Journal volume & issue: Vol. 5, no. 1
pp. 147 – 152

Abstract

Read online

Abstract After initiating combined antiretroviral therapy (cART), individuals with human immunodeficiency virus (HIV) may develop Hodgkin/non‐Hodgkin lymphoma due to immune reconstitution inflammatory syndrome (IRIS). This retrospective cohort study evaluated the incidence, clinical features and prognosis of IRIS‐associated lymphomas in Brazilian patients. Incidence in 2000–2019 was 9.8% (27/276 patients with HIV and lymphoma; viral load drop >1 log). Time between HIV diagnosis and cART initiation was <1 year in 70.3% of cases. Time between cART initiation and lymphoma diagnosis was <3 months in 11 cases and 3–6 months in 16 cases. Overall and progression‐free survival rates were similar between cases of non‐IRIS‐associated lymphoma and IRIS‐associated lymphoma.

Published in eJHaem

ISSN: 2688-6146 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the blood and blood-forming organs
Website: https://onlinelibrary.wiley.com/journal/26886146

About the journal

Abstract

Keywords