Calculation of the Damage Induced by Radionuclide 125I at Different Intervals from the DNA Central Axis based on an Atomic Model using the Geant4-DNA Toolkit

Abstract

Introduction: This study proposed a method to investigate the damage caused by Auger emitter radionuclide radiation. Materials & Methods: This study investigated the detailed rate of breaks induced by iodine radionuclide at different intervals from the DNA center using the Geant4-DNA toolkit and based on the atomic geometric model. Findings: The mean number of breaks in DNA is shown as a function of distance from the center of the DNA axis to the position of Auger emission radionuclide decay. Discussions & Conclusions: The highest damage occurs by electrons with energies below 1 keV, especially in the proximity of DNA.

Keywords

• auger electron
• double strand break
• geant4-dna
• radionuclide