The influence of CASP8 D302H gene variant in colorectal cancer risk and prognosis

Abstract

Apoptosis is defined as programmed cell death, which regulates cellular functions and various physiological responses. Several studies reported that Caspase genes play important roles in the apoptosis and inflammation process. Caspase-8 (CASP8) is a member of the cysteine protease family and a key regulator gene in the induction of apoptosis. In present study, we aimed to investigate the possible associations between the CASP8; D302H (G>C) gene polymorphism and colorectal cancer risk and prognosis.

Keywords

• apoptosis
• caspase-8
• colorectal cancer
• gene variation
• prognosis