The clinical value of preoperative peripheral blood platelet-to-monocyte ratio in the prognosis of colon cancer patients

Abstract

Objective To investigate the clinical significance of platelet-to-monocyte ratio (PMR) in prognosis of colon cancer patients. Methods Preoperative peripheral blood routine indicators and clinicopathological data of 167 patients with surgical resection and pathological diagnosis of colon cancer from March 2015 to January 2019 in Wujin Hospital Affiliated to Jiangsu University were retrospectively collected. The relationship between PMR and clinicopathological characteristics of colon cancer patients, and Cox regression was used to analyze the relationship between PMR, clinicopathological features and prognosis of colon cancer patients. Results The PMR of patients with different genders and ages had statistically significant difference(P<0.05). Binary logistic univariate analysis showed that PMR, lymph node metastasis, TNM stage and degree of differentiation were correlated with overall survival of colon cancer patients (P<0.05). Cox regression analysis showed that PMR, lymph node metastasis, TNM stage and differentiation degree were independent prognostic factors for colon cancer patients(P<0.05). Conclusion Preoperative PMR in peripheral blood may be an important indicator of prognosis in patients with colon cancer.

Keywords

• platelet-to-monocyte ratio
• platelet
• monocyte
• colon cancer
• overall survival
• prognosis