The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells

Jasmine C. Moody; Hiroshi Qadota; April R. Reedy; C. Denise Okafor; Niveda Shanmugan; Yohei Matsunaga; Courtney J. Christian; Eric A. Ortlund; Guy M. Benian

doi:10.1038/s41467-020-18852-4

Nature Communications (Oct 2020)

The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells

Jasmine C. Moody,
Hiroshi Qadota,
April R. Reedy,
C. Denise Okafor,
Niveda Shanmugan,
Yohei Matsunaga,
Courtney J. Christian,
Eric A. Ortlund,
Guy M. Benian

Affiliations

Jasmine C. Moody: Department of Pathology, Emory University
Hiroshi Qadota: Department of Pathology, Emory University
April R. Reedy: Department of Pathology, Emory University
C. Denise Okafor: Department of Biochemistry, Emory University
Niveda Shanmugan: Department of Pathology, Emory University
Yohei Matsunaga: Department of Pathology, Emory University
Courtney J. Christian: Department of Pathology, Emory University
Eric A. Ortlund: Department of Biochemistry, Emory University
Guy M. Benian: Department of Pathology, Emory University

DOI: https://doi.org/10.1038/s41467-020-18852-4
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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PIX proteins activate the small GTPases Rac and Cdc42, and are known to have numerous functions in a variety of cell types. Using a genetic screen in C. elegans, the authors find that PIX-1 is required for the assembly or stability of integrin adhesion complexes between muscle cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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