PLoS ONE (Jan 2013)

Associations between genetic polymorphisms in IL-33, IL1R1 and risk for inflammatory bowel disease.

  • Anna Latiano,
  • Orazio Palmieri,
  • Luca Pastorelli,
  • Maurizio Vecchi,
  • Theresa T Pizarro,
  • Fabrizio Bossa,
  • Giuseppe Merla,
  • Bartolomeo Augello,
  • Tiziana Latiano,
  • Giuseppe Corritore,
  • Alessia Settesoldi,
  • Maria Rosa Valvano,
  • Renata D'Incà,
  • Laura Stronati,
  • Vito Annese,
  • Angelo Andriulli

DOI
https://doi.org/10.1371/journal.pone.0062144
Journal volume & issue
Vol. 8, no. 4
p. e62144

Abstract

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BackgroundRecent evidence suggests that the IL-33/IL1RL1 axis plays a critical role in several autoimmune and inflammatory disorders; however, its mechanistic role in inflammatory bowel disease (IBD) has not been clearly defined. We investigated the contribution of IL-33 and IL1RL1 polymorphisms to IBD risk, and possible correlations with phenotype in an Italian cohort of adult and pediatric patients.MethodsWe evaluated the association of six SNPs in IL-33 and IL1RL1 genes, in 805 Crohn's disease (CD), 816 ulcerative colitis (UC), and 752 controls, using Taqman. IL-33 and IL1RL1 mRNA expression was also analyzed.ResultsSignificant allele and genotype associations with IL-33 rs3939286 were found in CD (P = 0.004; P = 0.035) and UC patients (P = 0.002; P = 0.038). After stratifying the cohort for age at diagnosis, the differences remained significant only in the IBD adult-onset. Significant associations were also obtained in CD patients with two IL1RL1 polymorphisms (rs13015714 and rs2058660, PConclusionsCommon IL-33 and IL1RL1 polymorphisms contribute to the risk of IBD in an Italian cohort of adult and pediatric patients, with some influence on sub-phenotypes.