A robust and tunable halogen bond organocatalyzed 2-deoxyglycosylation involving quantum tunneling

Abstract

Halogen bonding (HB) catalysis is rapidly gaining momentum, however, cases of XB activation for challenging bonds formation are rare. Here, the authors show a robust XB catalyzed 2-deoxyglycosylation with broad scope and featuring a quantum tunneling phenomenon in the proton transfer rate determining step.