Activation of Innate Immunity Human Cells by Lipopolisaccharide and Extracellular Polysaccharid Produced by Marine Bacteria

Abstract

It has been shown that using the cytometric method lipopolysaccharide (LPS) and extracellular polysaccharide (EPS) isolated from marine bacteria Pseudoalteromonas nigrifaciens increase the relative amount of monocytes synthesizing IL-12. LPS and EPS enhance the cytotoxic potential of NK cells, enhancing their degranulation (expression of membrane CD107a), intracellular synthesis of IFN-y and increasing the expression of CD25, CD69, HLA-DR, CD11b, and CD54 molecules.

Keywords

• pseudoalteromonas nigrifaciens
• nk-клетки
• marine bacteria
• pseudoalteromonas nigrifaciens
• innate immunity
• lipopolysaccharide
• extracellular polysaccharide
• nk cells
• cd107a
• intracellular cytokines