MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis

Abstract

Blocking lymphangiogenesis holds great therapeutic potential, however, only few inhibitors are known. Here the authors show that membrane type 1-matrix metalloproteinase suppresses lymphangiogenesis by curbing both LYVE-1-mediated proliferation of lymphatic endothelial cells and production of lymphangiogenic factors by macrophages.