Transport of a kinesin-cargo pair along microtubules into dendritic spines undergoing synaptic plasticity

Derrick P. McVicker; Adam M. Awe; Karl E. Richters; Rebecca L. Wilson; Diana A. Cowdrey; Xindao Hu; Edwin R. Chapman; Erik W. Dent

doi:10.1038/ncomms12741

Nature Communications (Sep 2016)

Transport of a kinesin-cargo pair along microtubules into dendritic spines undergoing synaptic plasticity

Derrick P. McVicker,
Adam M. Awe,
Karl E. Richters,
Rebecca L. Wilson,
Diana A. Cowdrey,
Xindao Hu,
Edwin R. Chapman,
Erik W. Dent

Affiliations

Derrick P. McVicker: Department of Neuroscience, University of Wisconsin, School of Medicine and Public Health
Adam M. Awe: Department of Neuroscience, University of Wisconsin, School of Medicine and Public Health
Karl E. Richters: Department of Neuroscience, University of Wisconsin, School of Medicine and Public Health
Rebecca L. Wilson: Department of Neuroscience, University of Wisconsin, School of Medicine and Public Health
Diana A. Cowdrey: Department of Neuroscience, University of Wisconsin, School of Medicine and Public Health
Xindao Hu: Department of Neuroscience, University of Wisconsin, School of Medicine and Public Health
Edwin R. Chapman: Department of Neuroscience, University of Wisconsin, School of Medicine and Public Health
Erik W. Dent: Department of Neuroscience, University of Wisconsin, School of Medicine and Public Health

DOI: https://doi.org/10.1038/ncomms12741
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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Transport of cargo into dendritic spines is required for synaptic plasticity. McVicker et al.describe a method of activity-dependent transport of a kinesin KIF1A and its cargo synaptotagmin-IV along microtubules that are transiently polymerized into dendritic spines.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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