Striking Plasticity of CRISPR-Cas9 and Key Role of Non-target DNA, as Revealed by Molecular Simulations

• Giulia Palermo,
• Yinglong Miao,
• Ross C. Walker,
• Martin Jinek,
• J. Andrew McCammon

Affiliations

Giulia Palermo

Department of Pharmacology, University of California San Diego, La Jolla, California, United States

Yinglong Miao

Department of Pharmacology, University of California San Diego, La Jolla, California, United States

Ross C. Walker

San Diego Supercomputer Center, University of California San Diego, La Jolla, California, United States

Martin Jinek

Department of Biochemistry, University of Zurich, Zurich, Switzerland

J. Andrew McCammon

Department of Pharmacology, University of California San Diego, La Jolla, California, United States