Nature Communications (Aug 2020)
Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome
- Valeria Capaci,
- Lorenzo Bascetta,
- Marco Fantuz,
- Galina V. Beznoussenko,
- Roberta Sommaggio,
- Valeria Cancila,
- Andrea Bisso,
- Elena Campaner,
- Alexander A. Mironov,
- Jacek R. Wiśniewski,
- Luisa Ulloa Severino,
- Denis Scaini,
- Fleur Bossi,
- Jodi Lees,
- Noa Alon,
- Ledia Brunga,
- David Malkin,
- Silvano Piazza,
- Licio Collavin,
- Antonio Rosato,
- Silvio Bicciato,
- Claudio Tripodo,
- Fiamma Mantovani,
- Giannino Del Sal
Affiliations
- Valeria Capaci
- Laboratorio Nazionale CIB (LNCIB)
- Lorenzo Bascetta
- Laboratorio Nazionale CIB (LNCIB)
- Marco Fantuz
- Laboratorio Nazionale CIB (LNCIB)
- Galina V. Beznoussenko
- Fondazione Istituto FIRC di Oncologia Molecolare (IFOM)
- Roberta Sommaggio
- Veneto Institute of Oncology IOV-IRCCS
- Valeria Cancila
- Tumor Immunology Unit, Department of Health Science, Human Pathology Section, University of Palermo, School of Medicine
- Andrea Bisso
- Laboratorio Nazionale CIB (LNCIB)
- Elena Campaner
- Laboratorio Nazionale CIB (LNCIB)
- Alexander A. Mironov
- Fondazione Istituto FIRC di Oncologia Molecolare (IFOM)
- Jacek R. Wiśniewski
- Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry
- Luisa Ulloa Severino
- Dipartimento di Scienze della Vita, Università degli Studi di Trieste
- Denis Scaini
- International School for Advanced Studies (SISSA)
- Fleur Bossi
- Dipartimento di Scienze della Vita, Università degli Studi di Trieste
- Jodi Lees
- Genetics and Genome Biology Program, The Hospital for Sick Children
- Noa Alon
- Genetics and Genome Biology Program, The Hospital for Sick Children
- Ledia Brunga
- Genetics and Genome Biology Program, The Hospital for Sick Children
- David Malkin
- Genetics and Genome Biology Program, The Hospital for Sick Children
- Silvano Piazza
- Laboratorio Nazionale CIB (LNCIB)
- Licio Collavin
- Laboratorio Nazionale CIB (LNCIB)
- Antonio Rosato
- Veneto Institute of Oncology IOV-IRCCS
- Silvio Bicciato
- Center for Genome Research, University of Modena and Reggio Emilia
- Claudio Tripodo
- Tumor Immunology Unit, Department of Health Science, Human Pathology Section, University of Palermo, School of Medicine
- Fiamma Mantovani
- Laboratorio Nazionale CIB (LNCIB)
- Giannino Del Sal
- Laboratorio Nazionale CIB (LNCIB)
- DOI
- https://doi.org/10.1038/s41467-020-17596-5
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 19
Abstract
p53 mutants can promote tumorigenesis by affecting fundamental cellular pathways and functions. In this study, the authors demonstrate a novel mutant-p53/HIF1α/miR-30d axis that impacts Golgi structure, trafficking, and secretion of proteins essential for tumor growth and metastasis.
