Advances in the study of tissue-engineered retinal pigment epithelial cell sheets

Wang Zhou; Yujiao Chai; Shan Lu; Qiaohui Yang; Liying Tang; Di Zhou

Regenerative Therapy (Dec 2024)

Advances in the study of tissue-engineered retinal pigment epithelial cell sheets

Wang Zhou,
Yujiao Chai,
Shan Lu,
Qiaohui Yang,
Liying Tang,
Di Zhou

Affiliations

Wang Zhou: NHC Key Laboratory of Human Stem and Reproductive Engineering, School of Basic Medical Science, Central South University, Changsha, China; National Engineering Research Center of Human Stem Cells, Changsha, China
Yujiao Chai: NHC Key Laboratory of Human Stem and Reproductive Engineering, School of Basic Medical Science, Central South University, Changsha, China; National Engineering Research Center of Human Stem Cells, Changsha, China
Shan Lu: National Engineering Research Center of Human Stem Cells, Changsha, China; Hunan Guangxiu Hospital, Hunan Normal University, Changsha, China
Qiaohui Yang: NHC Key Laboratory of Human Stem and Reproductive Engineering, School of Basic Medical Science, Central South University, Changsha, China; Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, China
Liying Tang: NHC Key Laboratory of Human Stem and Reproductive Engineering, School of Basic Medical Science, Central South University, Changsha, China; National Engineering Research Center of Human Stem Cells, Changsha, China
Di Zhou: NHC Key Laboratory of Human Stem and Reproductive Engineering, School of Basic Medical Science, Central South University, Changsha, China; National Engineering Research Center of Human Stem Cells, Changsha, China; Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, China; National Center for Drug Evaluation, National Medical Products Administration, Beijing, China; Corresponding author. NHC Key Laboratory of Human Stem and Reproductive Engineering, School of Basic Medical Science, Central South University, 8 Luyun Road, Yuelu District, Changsha, Hunan, 410205, China.

Journal volume & issue: Vol. 27
pp. 419 – 433

Abstract

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Regarded as the most promising treatment modality for retinal degenerative diseases, retinal pigment epithelium cell replacement therapy holds significant potential. Common retinal degenerative diseases, including Age-related Macular Degeneration, are frequently characterized by damage to the unit comprising photoreceptors, retinal pigment epithelium, and Bruch's membrane. The selection of appropriate tissue engineering materials, in conjunction with retinal pigment epithelial cells, for graft preparation, can offer an effective treatment for retinal degenerative diseases. This article presents an overview of the research conducted on retinal pigment epithelial cell tissue engineering, outlining the challenges and future prospects.

Published in Regenerative Therapy

ISSN: 2352-3204 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General); Science: Biology (General): Cytology
Website: http://www.journals.elsevier.com/regenerative-therapy/

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Abstract

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