Nature Communications (Sep 2017)
Tau exacerbates excitotoxic brain damage in an animal model of stroke
- Mian Bi,
- Amadeus Gladbach,
- Janet van Eersel,
- Arne Ittner,
- Magdalena Przybyla,
- Annika van Hummel,
- Sook Wern Chua,
- Julia van der Hoven,
- Wei S. Lee,
- Julius Müller,
- Jasneet Parmar,
- Georg von Jonquieres,
- Holly Stefen,
- Ernesto Guccione,
- Thomas Fath,
- Gary D. Housley,
- Matthias Klugmann,
- Yazi D. Ke,
- Lars M. Ittner
Affiliations
- Mian Bi
- Dementia Research Unit (DRU), School of Medical Sciences, The University of New South Wales
- Amadeus Gladbach
- Dementia Research Unit (DRU), School of Medical Sciences, The University of New South Wales
- Janet van Eersel
- Dementia Research Unit (DRU), School of Medical Sciences, The University of New South Wales
- Arne Ittner
- Dementia Research Unit (DRU), School of Medical Sciences, The University of New South Wales
- Magdalena Przybyla
- Dementia Research Unit (DRU), School of Medical Sciences, The University of New South Wales
- Annika van Hummel
- Dementia Research Unit (DRU), School of Medical Sciences, The University of New South Wales
- Sook Wern Chua
- Dementia Research Unit (DRU), School of Medical Sciences, The University of New South Wales
- Julia van der Hoven
- Dementia Research Unit (DRU), School of Medical Sciences, The University of New South Wales
- Wei S. Lee
- Dementia Research Unit (DRU), School of Medical Sciences, The University of New South Wales
- Julius Müller
- Division of Cancer Genetics and Therapeutics, Laboratory of Chromatin, Epigenetics & Differentiation, Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research)
- Jasneet Parmar
- Translational Neuroscience Facility and Department of Physiology, School of Medical Sciences, The University of New South Wales
- Georg von Jonquieres
- Translational Neuroscience Facility and Department of Physiology, School of Medical Sciences, The University of New South Wales
- Holly Stefen
- Neuron Culture Core Facility (NCCF), The University of New South Wales
- Ernesto Guccione
- Division of Cancer Genetics and Therapeutics, Laboratory of Chromatin, Epigenetics & Differentiation, Institute of Molecular and Cell Biology, A*STAR (Agency for Science, Technology and Research)
- Thomas Fath
- Neuron Culture Core Facility (NCCF), The University of New South Wales
- Gary D. Housley
- Translational Neuroscience Facility and Department of Physiology, School of Medical Sciences, The University of New South Wales
- Matthias Klugmann
- Translational Neuroscience Facility and Department of Physiology, School of Medical Sciences, The University of New South Wales
- Yazi D. Ke
- Dementia Research Unit (DRU), School of Medical Sciences, The University of New South Wales
- Lars M. Ittner
- Dementia Research Unit (DRU), School of Medical Sciences, The University of New South Wales
- DOI
- https://doi.org/10.1038/s41467-017-00618-0
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 15
Abstract
Excitotoxicity contributes to neuronal injury following stroke. Here the authors show that tau promotes excitotoxicity by a post-synaptic mechanism, involving site-specific control of ERK activation, in a mouse model of stroke.
