World Allergy Organization Journal (Aug 2024)
Profiling severe asthma: Any relevance for age? An analysis from Severe Asthma Network Italy (SANI) cohort
- Marco Caminati, MD,
- Alessandro Marcon, PhD,
- Rachele Vaia, MD,
- Gianenrico Senna, MD,
- Matteo Maule, MD,
- Pierpaolo Marchetti, MD,
- Jessica Miotti, MD,
- Giuseppe Argentino, MD,
- Francesco Blasi, MD, PhD,
- Giorgio W. Canonica, MD,
- Enrico M. Heffler, MD, PhD,
- Pierluigi Paggiaro, MD,
- Andrea Vianello, MD, PhD,
- Gabriella Guarnieri, MD,
- Luisa Brussino, MD PhD, S.S.D.D.U,
- Cecilia Calabrese, MD PhD,
- Gianna Camiciottoli, MD,
- Giovanna E. Carpagnano, MD PhD,
- Stefano Centanni, MD PhD,
- Angelo G. Corsico, MD PhD,
- Maria T. Costantino, MD,
- Claudia Crimi, MD PhD,
- Alice D'adda, MD,
- Simona D'alo, MD,
- Maria D'amato, MD PhD,
- Stefano Del Giacco, MD,
- Fabiano Di Marco, MD PhD,
- Nicola C. Facciolongo, MD,
- Manuela Latorre, MD PhD,
- Eustachio Nettis, MD,
- Eleonora Nucera, MD,
- Giovanni Passalacqua, MD,
- Girolamo Pelaia, MD,
- Laura Pini, MD PhD,
- Luisa Ricciardi, MD,
- Luca Richeldi, MD,
- Erminia Ridolo, MD PhD,
- Pierachille Santus, MD PhD,
- Nicola Scichilone, MD,
- Giulia Scioscia, MD PhD,
- Giuseppe Spadaro, MD,
- Antonio Spanevello, MD PhD,
- Paolo Tarsia, MD PhD
Affiliations
- Marco Caminati, MD
- Department of Medicine, University of Verona, Verona, Italy; Asthma Center and Allergy Unit, Verona University Hospital, Verona, Italy; Corresponding author. Department of Medicine, University of Verona, Verona, Italy.
- Alessandro Marcon, PhD
- Department of Diagnostics and Public Health, Unit of Epidemiology and Medical Statistics, University of Verona, Verona, Italy
- Rachele Vaia, MD
- Department of Medicine, University of Verona, Verona, Italy; Asthma Center and Allergy Unit, Verona University Hospital, Verona, Italy
- Gianenrico Senna, MD
- Department of Medicine, University of Verona, Verona, Italy; Asthma Center and Allergy Unit, Verona University Hospital, Verona, Italy
- Matteo Maule, MD
- Department of Medicine, University of Verona, Verona, Italy; Asthma Center and Allergy Unit, Verona University Hospital, Verona, Italy
- Pierpaolo Marchetti, MD
- Department of Diagnostics and Public Health, Unit of Epidemiology and Medical Statistics, University of Verona, Verona, Italy
- Jessica Miotti, MD
- Department of Diagnostics and Public Health, Unit of Epidemiology and Medical Statistics, University of Verona, Verona, Italy
- Giuseppe Argentino, MD
- Department of Medicine, University of Verona, Verona, Italy
- Francesco Blasi, MD, PhD
- Internal Medicine Department, Respiratory Unit and Cystic Fibrosis Center, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy
- Giorgio W. Canonica, MD
- Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy; Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center, IRCCS, Rozzano, Milano, Italy
- Enrico M. Heffler, MD, PhD
- Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy; Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center, IRCCS, Rozzano, Milano, Italy
- Pierluigi Paggiaro, MD
- Department of Surgery, Medicine, Molecular Biology and Critical Care, University of Pisa, Pisa, Italy
- Andrea Vianello, MD, PhD
- Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy
- Gabriella Guarnieri, MD
- Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy
- Luisa Brussino, MD PhD, S.S.D.D.U
- Immunologia Clinica e Allergologia, Ospedale Mauriziano, Torino, Italy
- Cecilia Calabrese, MD PhD
- Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy
- Gianna Camiciottoli, MD
- UNIT ASMA GRAVE - Ambulatorio Asma Grave Pneumologia e Fisiopatologia Toraco-Polmonare, Azienda Ospedaliera Universitaria Careggi (FI), Florence, Italy
- Giovanna E. Carpagnano, MD PhD
- Department of Translational Biomedicine and Neuroscience“DiBraiN”, University of Bari Aldo Moro, Bari, Italy; Section of Respiratory Diseases, Policlinico Hospital of Bari, Italy
- Stefano Centanni, MD PhD
- Respiratory Unit, ASST Santi Paolo e Carlo, San Paolo Hospital, Department of Health Sciences, University of Milan, Milan, Italy
- Angelo G. Corsico, MD PhD
- Division of Respiratory Diseases, IRCCS Policlinico San Matteo, Foundation and Department of Internal Medicine and Therapeutics, University of Pavia, Italy
- Maria T. Costantino, MD
- Allergy and Clinical Immunology Unit, Department of Medicine, “Carlo Poma” Hospital Mantova, Italy
- Claudia Crimi, MD PhD
- Respiratory Medicine Unit, Policlinico “G. Rodolico-San Marco” University Hospital, Catania, Italy
- Alice D'adda, MD
- Broncopneumologia, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
- Simona D'alo, MD
- UOC Allergologia PO Civitanova Marche AREA VASTA 3, Civitanova Marche, Italy
- Maria D'amato, MD PhD
- Department of Respiratory Medicine, University “Federico II” of Naples, Italy
- Stefano Del Giacco, MD
- Unit of Allergy and Clinical Immunology, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy
- Fabiano Di Marco, MD PhD
- Pulmonary Medicine Unit, ASST Papa Giovanni XXIII Hospital, Bergamo, Italy
- Nicola C. Facciolongo, MD
- UOC di Pneumologia, Arcispedale S. Maria Nuova Azienda USL di Reggio Emilia, Italy
- Manuela Latorre, MD PhD
- Pulmonary Unit, Nuovo Ospedale Apuano, Massa, Italy
- Eustachio Nettis, MD
- Department of Emergency and Organ Transplantation, School and Chair of Allergology and Clinical Immunology, University of Bari, Bari, Italy
- Eleonora Nucera, MD
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore Roma, Italy; UOSD Allergologia e Immunologia Clinica, Dipartimento Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS Roma, Italy
- Giovanni Passalacqua, MD
- Clinica di Malattie Respiratorie e Allergologia, Dip. Medicina Interna, Univ. degli Studi di Genova, IRCCS-AOU San Martino, Genoa, Italy
- Girolamo Pelaia, MD
- U.O. Malattie dell’Apparato Respiratorio, A.O.U. Mater Domini, Catanzaro, Italy
- Laura Pini, MD PhD
- Department of Clinical and Experimental Sciences, University of Brescia - ASST Spedali Civili di Brescia, Italy
- Luisa Ricciardi, MD
- Allergologia e Immunologia Clinica, AOU Policlinico G. Martino - Università di Messina, Messina Italy
- Luca Richeldi, MD
- Fondazione Policlinico Universitario A. Gemelli, IRCCS Catholic University of Rome, Italy
- Erminia Ridolo, MD PhD
- Department of Medicine and Surgery, University of Parma, Parma, Italy
- Pierachille Santus, MD PhD
- Department of Clinical and Biomedical Sciences, University of Milan, Respiratory Diseases, Sacco University Hospital, ASST Fatebenefratelli-Sacco, Milan, Italy
- Nicola Scichilone, MD
- U.O.C. Pneumologia, Azienda Ospedaliera Universitaria Policlinico P. Giaccone di Palermo, Italy
- Giulia Scioscia, MD PhD
- Malattie Apparato Respiratorio, Dipartimenti delle funzioni Mediche e Sanitarie, Azienda Ospedaliero Universitaria - Ospedali Riuniti, Foggia, Italy
- Giuseppe Spadaro, MD
- Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, Naples, Italy
- Antonio Spanevello, MD PhD
- Pneumologia Riabilitativa, ICS Maugeri IRCCS Tradate, Tradate (VA), Italy
- Paolo Tarsia, MD PhD
- Pneumology Unit, Grande Ospedale Metropolitano Niguarda, Milan, Italy
- Journal volume & issue
-
Vol. 17,
no. 8
p. 100941
Abstract
Background: Aging implies changes in terms of lung function, immune system, and respiratory and extra-respiratory comorbidities. Few studies have specifically addressed the relevance of age on severe asthma burden and control. We aimed to evaluate whether age acts as an independent determinant of asthma severity, in terms of clinical, functional, and inflammatory profile, and to explore potential cofactors that contribute to a more difficult disease control in different age groups. Methods: Patients from Severe Asthma Network Italy (SANI) registry were retrospectively divided in subgroups according to their age. Cutoffs for age were established according to quartiles in order to obtain a comparable number of patients for each group, and then rounded for the sake of simplicity. Results: Overall, 1805 severe asthma patients were analyzed. Lung function represented the most important age-related variable. On the opposite the level of asthma control was not differently distributed among age ranges. In young people the presence of atopy-related comorbidities (allergic rhinitis, atopic dermatitis) predominated, whilst systemic-metabolic and degenerative comorbidities such as diabetes, cardiovascular diseases, anxious-depressive syndrome, and osteoporosis prevailed in elderly. Bronchiectasis and sleep disturbances were significantly associated with age. Conclusions: Despite that it cannot be considered a treatable trait, our study suggests that age should be evaluated within a personalized approach to severe asthma patients, in order to provide a better clinical profiling and a more tailored treatment strategy.
