A single m6A modification in U6 snRNA diversifies exon sequence at the 5’ splice site

Yuma Ishigami; Takayuki Ohira; Yui Isokawa; Yutaka Suzuki; Tsutomu Suzuki

doi:10.1038/s41467-021-23457-6

Nature Communications (May 2021)

A single m6A modification in U6 snRNA diversifies exon sequence at the 5’ splice site

Yuma Ishigami,
Takayuki Ohira,
Yui Isokawa,
Yutaka Suzuki,
Tsutomu Suzuki

Affiliations

Yuma Ishigami: Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo
Takayuki Ohira: Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo
Yui Isokawa: Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo
Yutaka Suzuki: Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo
Tsutomu Suzuki: Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo

DOI: https://doi.org/10.1038/s41467-021-23457-6
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Spliceosomal U6 snRNA is modified by m6A. Here the authors show that m6A modification on U6 snRNA promotes efficient recognition of the splice site through cooperating with U5 snRNA, indicating that U6 snRNA m6A allows the 5’ exon sequence variation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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