CYFRA 21-1 in patients with suspected cancer: evaluation of an optimal cutoff to assess the diagnostic efficacy and prognostic value

Garcia-Valdecasas Gayo Sonsoles; Ruiz-Alvarez Maria Jesus; Gonzalez-Gay Daniel; Ramos-Corral Raquel; Marquez-Lietor Eva; Del Amo Nazaret; Plata Maria del Carmen; Guillén-Santos Raquel; Arribas Ignacio; Cava-Valenciano Fernando

doi:10.1515/almed-2020-0005

Advances in Laboratory Medicine (Oct 2020)

CYFRA 21-1 in patients with suspected cancer: evaluation of an optimal cutoff to assess the diagnostic efficacy and prognostic value

Garcia-Valdecasas Gayo Sonsoles,
Ruiz-Alvarez Maria Jesus,
Gonzalez-Gay Daniel,
Ramos-Corral Raquel,
Marquez-Lietor Eva,
Del Amo Nazaret,
Plata Maria del Carmen,
Guillén-Santos Raquel,
Arribas Ignacio,
Cava-Valenciano Fernando

Affiliations

Garcia-Valdecasas Gayo Sonsoles: Central Laboratory BR Salud, Department of Clinical Chemistry, Infanta Sofia University Hospital, San Sebastian de los Reyes, Madrid, Spain
Ruiz-Alvarez Maria Jesus: Central Laboratory BR Salud, Department of Clinical Chemistry, Infanta Sofia University Hospital, San Sebastian de los Reyes, Madrid, Spain
Gonzalez-Gay Daniel: Central Laboratory BR Salud, Department of Clinical Chemistry, Infanta Sofia University Hospital, San Sebastian de los Reyes, Madrid, Spain
Ramos-Corral Raquel: Central Laboratory BR Salud, Department of Clinical Chemistry, Infanta Sofia University Hospital, San Sebastian de los Reyes, Madrid, Spain
Marquez-Lietor Eva: Central Laboratory BR Salud, Department of Clinical Chemistry, Infanta Sofia University Hospital, San Sebastian de los Reyes, Madrid, Spain
Del Amo Nazaret: Central Laboratory BR Salud, Department of Clinical Chemistry, Infanta Sofia University Hospital, San Sebastian de los Reyes, Madrid, Spain
Plata Maria del Carmen: Central Laboratory BR Salud, Department of Clinical Chemistry, Infanta Sofia University Hospital, San Sebastian de los Reyes, Madrid, Spain
Guillén-Santos Raquel: Central Laboratory BR Salud, Department of Clinical Chemistry, Infanta Sofia University Hospital, San Sebastian de los Reyes, Madrid, Spain
Arribas Ignacio: Department of Clinical Chemistry, Ramón y Cajal University Hospital, San Sebastian de los Reyes, Madrid, Spain
Cava-Valenciano Fernando: Central Laboratory BR Salud, Department of Clinical Chemistry, Infanta Sofia University Hospital, San Sebastian de los Reyes, Madrid, Spain

DOI: https://doi.org/10.1515/almed-2020-0005
Journal volume & issue: Vol. 1, no. 4
pp. 160 – 5

Abstract

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Chosen cutoff for cytokeratin 19 fragment antigen (CYFRA 21-1) as a tumor biomarker considerably influences its diagnostic and prognostic usefulness. The aim of the present study is to determine an optimal cutoff value for diagnostic validity of CYFRA 21-1 by Lumipulse ® technology in patients with suspected cancer and also to determine if CYFRA 21-1 levels provide prognostic value.

Published in Advances in Laboratory Medicine

ISSN: 2628-491X (Online)
Publisher: De Gruyter
Country of publisher: Germany
LCC subjects: Medicine: Medicine (General): Medical technology
Website: https://www.degruyter.com/journal/key/almed/html

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