International Medical Case Reports Journal (Jun 2023)
The Elusive SLIPPERS Syndrome (Supratentorial Lymphocytic Inflammation with Parenchymal Perivascular Enhancement Responsive to Steroids): A Case Report and Literature Review
Abstract
Adnan Khan,1 Muhammad Mohsin Khan,1 Issam A Al-Bozom,2 Younis Baregzai,1 Wanis Ibrahim,3 Firas Hammadi1 1Department of Neurosurgery, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar; 2Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar; 3Department of Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, QatarCorrespondence: Muhammad Mohsin Khan, Hamad Medical Corporation, Doha, Qatar, Tel +97466113950, Email [email protected]: In 2015, the term “SLIPPERS” was created to refer to a rare type of encephalomyelitis called CLIPPERS syndrome that affects the pons and sometimes other nearby structures, but in this case, it primarily affects the supratentorial region. This variation of the condition is responsive to treatment with steroids.Case Description: We report the case of a patient who presented with seizures and visual field deficit and had typical radiological and histopathological characteristics of SLIPPERS syndrome.Conclusion: Although the literature is inundated with CLIPPERS syndrome, its supratentorial variant is extremely rare. To our knowledge, this is fourth case of SLIPPERS syndrome to be reported in literature and serves to enhance clinicopathological understanding of this elusive entity.Keywords: CLIPPERS, SLIPPERS, corticosteroids, neuroinflammation, perivascular infiltration
