Frontiers in Pharmacology (Oct 2022)

Regulation of transient receptor potential channels by traditional Chinese medicines and their active ingredients

  • Shidu Yan,
  • Shidu Yan,
  • Shidu Yan,
  • Yuchan Huang,
  • Yuchan Huang,
  • Yuchan Huang,
  • Qian Xiao,
  • Qian Xiao,
  • Qian Xiao,
  • Zixia Su,
  • Zixia Su,
  • Zixia Su,
  • Lei Xia,
  • Lei Xia,
  • Lei Xia,
  • Jinling Xie,
  • Jinling Xie,
  • Jinling Xie,
  • Fan Zhang,
  • Fan Zhang,
  • Fan Zhang,
  • Zhengcai Du,
  • Zhengcai Du,
  • Zhengcai Du,
  • Xiaotao Hou,
  • Xiaotao Hou,
  • Xiaotao Hou,
  • Jiagang Deng,
  • Jiagang Deng,
  • Jiagang Deng,
  • Erwei Hao,
  • Erwei Hao,
  • Erwei Hao

DOI
https://doi.org/10.3389/fphar.2022.1039412
Journal volume & issue
Vol. 13

Abstract

Read online

In recent years, activation of thermal transient receptor potential (TRP) ion channels at a range of temperatures has received widespread attention as a target for traditional Chinese medicine (TCM) to regulate body temperature and relieve pain. Discovery of transient receptor potential vanilloid 1 (TRPV1) was awarded a Nobel Prize, reflecting the importance of these channels. Here, the regulatory effects of TCMs and their active ingredients on TRP ion channels are reviewed, and future directions for research on the cold, hot, warm, cool, and neutral natures of TCMs are considered. In herbs with cold, hot, warm, cool, and neutral natures, we found 29 TCMs with regulatory effects on TRP ion channels, including Cinnamomi Cortex, Capsici Fructus, Rhei Radix et Rhizoma, Macleayae cordatae Herba, Menthae Haplocalycis Herba, and Rhodiolae Crenulatae Radix et Rhizoma. Although some progress has been made in understanding the regulation of TRP ion channels by TCMs and their ingredients, the molecular mechanism by which TCMs have this effect remains to be further studied. We hope this review will provide a reference for further research on the cold, hot, warm, cool, and neutral natures of TCMs.

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