CLINICAL AND IMMUNOLOGICAL EFFICIENCY OF ADAMANTANE DERIVATIVE IN THERAPY OF ASTHENIC DISORDERS IN EARLY FORMS OF CHRONIC BRAIN ISCHEMIA

Abstract

A non-specific stress-induced overload of limbic-reticular emotiogenic structures under the deficiency conditions of endogenous energy resources is the main mechanism for development of asthenic disorders with early developing chronic brain ischemia among veterans of recent wars, upon their return to civilian life. We observed a group of 30 Afghan veterans with early forms of chronic brain ischemia and manifestations of psychogenic asthenic syndrome. When treating psychogenic asthenic syndrome in the veterans of recent military conflicts, an adamantane derivative administered as a course treatment, at a dose of 50 mg 2 times daily causes psychostimulant, anxiolytic, vegetotropic, antihypotymic, and hypnotic pharmacological effects, with reduction of main psychopathological and somatoneurological symptoms.A notable immunotropic effect of the drug was revealed, being expressed as enhanced immunopoiesis; activation of innate defense mechanisms; expansion of Treg lymphocyte population, suggestive for increased suppressor effect upon the mechanisms of autoimmune aggression; implementation of cell differentiation/ proliferative effect; anti-apoptogenic properties; anti-inflammatory activity (reduction of TNFα, IL-8, hsCRP, along with IL-2 increase) associated with reduced functional activity of mononuclear cells; vasotropic action expressed as normalized balance of vasoactive factors (nitric oxide, endothelin-1), decrease of nitrotyrosine concentration, suggesting the nitrosylation stress reduction. The actoprotective drug effect is implemented due to a combined psychostimulant, vasotropic, proliferative effects. It may be expressed in terms of higher efficiency and optimization of systemic hemodynamic parameters.

Keywords

• chronic brain ischemia
• asthenic syndrome
• ladasten
• immunotropic action