Nature Communications (Oct 2019)

RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype

  • Demin Cai,
  • Junjian Wang,
  • Bei Gao,
  • Jin Li,
  • Feng Wu,
  • June X. Zou,
  • Jianzhen Xu,
  • Yuqian Jiang,
  • Hongye Zou,
  • Zenghong Huang,
  • Alexander D. Borowsky,
  • Richard J. Bold,
  • Primo N. Lara,
  • Jian Jian Li,
  • Xinbin Chen,
  • Kit S. Lam,
  • Ka-Fai To,
  • Hsing-Jien Kung,
  • Oliver Fiehn,
  • Ruqian Zhao,
  • Ronald M. Evans,
  • Hong-Wu Chen

DOI
https://doi.org/10.1038/s41467-019-12529-3
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 17

Abstract

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Enhanced cholesterol biosynthesis is associated with cancer progression. Here the authors identify the nuclear receptor RORγ as a novel master regulator of cholesterol metabolism in triple negative breast cancer (TNBC) and find that RORγ small-molecule antagonists induce tumor regression in patient-derived xenografts and immunocompetent mouse models.