Metabolomics Reveal Potential Natural Substrates of AcrB in Escherichia coli and Salmonella enterica Serovar Typhimurium

Xuan Wang-Kan; Giovanny Rodríguez-Blanco; Andrew D. Southam; Catherine L. Winder; Warwick B. Dunn; Alasdair Ivens; Laura J. V. Piddock

doi:10.1128/mBio.00109-21

mBio (Apr 2021)

Metabolomics Reveal Potential Natural Substrates of AcrB in Escherichia coli and Salmonella enterica Serovar Typhimurium

Xuan Wang-Kan,
Giovanny Rodríguez-Blanco,
Andrew D. Southam,
Catherine L. Winder,
Warwick B. Dunn,
Alasdair Ivens,
Laura J. V. Piddock

Affiliations

Xuan Wang-Kan: Antimicrobials Research Group, Institute of Microbiology and Infection, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, United Kingdom
Giovanny Rodríguez-Blanco: School of Biosciences, The University of Birmingham, Birmingham, United Kingdom
Andrew D. Southam: School of Biosciences, The University of Birmingham, Birmingham, United Kingdom
Catherine L. Winder: School of Biosciences, The University of Birmingham, Birmingham, United Kingdom
Warwick B. Dunn: School of Biosciences, The University of Birmingham, Birmingham, United Kingdom
Alasdair Ivens: Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, United Kingdom
Laura J. V. Piddock: ORCiD; Antimicrobials Research Group, Institute of Microbiology and Infection, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, United Kingdom

DOI: https://doi.org/10.1128/mBio.00109-21
Journal volume & issue: Vol. 12, no. 2

Abstract

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Multidrug-resistant Gram-negative bacteria pose a global threat to human health. The AcrB efflux pump confers inherent and evolved drug resistance to EnterobacteralesEscherichia coliSalmonella enterica

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal