Synthesis of Functionalized Arylaziridines as Potential Antimicrobial Agents

Abstract

By using the Suzuki-Miyaura protocol, a simple straightforward synthesis of functionalized 2-arylaziridines has been developed. By means of this synthetic strategy from readily available ortho-, meta- and para-bromophenylaziridines and aryl- or heteroarylboronic acids, new aziridines could be obtained. The cross-coupling reactions occurred without ring opening of the three membered ring. Preliminary results on the antimicrobial activity of the heterosubstituted biaryl compounds have been also included.

Keywords

• aziridines
• boron compounds
• Suzuki-Miyaura
• palladium coupling
• antibiotics