Nature Communications (Dec 2018)
STING-dependent sensing of self-DNA drives silica-induced lung inflammation
- Sulayman Benmerzoug,
- Stéphanie Rose,
- Badreddine Bounab,
- David Gosset,
- Laure Duneau,
- Pauline Chenuet,
- Lucile Mollet,
- Marc Le Bert,
- Christopher Lambers,
- Silvana Geleff,
- Michael Roth,
- Louis Fauconnier,
- Delphine Sedda,
- Clarisse Carvalho,
- Olivier Perche,
- David Laurenceau,
- Bernhard Ryffel,
- Lionel Apetoh,
- Ahmet Kiziltunc,
- Hakan Uslu,
- Fadime Sultan Albez,
- Metin Akgun,
- Dieudonnée Togbe,
- Valerie F. J. Quesniaux
Affiliations
- Sulayman Benmerzoug
- CNRS, UMR7355
- Stéphanie Rose
- CNRS, UMR7355
- Badreddine Bounab
- CNRS, UMR7355
- David Gosset
- Center for Molecular Biophysics, CNRS UPR4301
- Laure Duneau
- CNRS, UMR7355
- Pauline Chenuet
- Artimmune SAS, rue Buffon
- Lucile Mollet
- Center for Molecular Biophysics, CNRS UPR4301
- Marc Le Bert
- CNRS, UMR7355
- Christopher Lambers
- Department of Thoracic Surgery, Lung Transplantation Program
- Silvana Geleff
- Clinical Institute of Pathology, Medical University of Vienna
- Michael Roth
- Pulmonary Cell Research & Pneumology, Department Biomedicine, University& University Hospital Basel
- Louis Fauconnier
- Artimmune SAS, rue Buffon
- Delphine Sedda
- CNRS, UMR7355
- Clarisse Carvalho
- CNRS, UMR7355
- Olivier Perche
- CNRS, UMR7355
- David Laurenceau
- CNRS, UMR7355
- Bernhard Ryffel
- CNRS, UMR7355
- Lionel Apetoh
- INSERM, U1231
- Ahmet Kiziltunc
- Department of Biochemistry, Atatürk University School of Medicine
- Hakan Uslu
- Department of Clinical Microbiology, Atatürk University School of Medicine
- Fadime Sultan Albez
- Department of Pulmonary Medicine, Atatürk University School of Medicine
- Metin Akgun
- Department of Pulmonary Medicine, Atatürk University School of Medicine
- Dieudonnée Togbe
- Artimmune SAS, rue Buffon
- Valerie F. J. Quesniaux
- CNRS, UMR7355
- DOI
- https://doi.org/10.1038/s41467-018-07425-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 19
Abstract
Silica particles induce intereukin-1 (IL-1) response to contribute to lung inflammation, but the underlying mechanism is unclear. Here the authors show that silica induces cell death and release of mitochondria and genomic DNA, which are sensed by STING with or without involving cGAS, respectively, for IL-1 induction and lung inflammation.
