The perinatal factors that influence the excretion of fecal calprotectin in premature-born children

Cekovic Jelena R.; Prodanovic Nikola S.; Mijailovic Sara S.; Knezevic Sanja M.; Vuletic Biljana P.; Stojkovic Andjelka K.; Savic Dragana M.; Prodanovic Tijana V.; Stanojevic Marina M.; Simovic Aleksandra M.

doi:10.1515/med-2022-0522

Open Medicine (Jul 2022)

The perinatal factors that influence the excretion of fecal calprotectin in premature-born children

Cekovic Jelena R.,
Prodanovic Nikola S.,
Mijailovic Sara S.,
Knezevic Sanja M.,
Vuletic Biljana P.,
Stojkovic Andjelka K.,
Savic Dragana M.,
Prodanovic Tijana V.,
Stanojevic Marina M.,
Simovic Aleksandra M.

Affiliations

Cekovic Jelena R.: Neonatal Intensive Care Unit, Center for Neonatology, Pediatric Clinic, University Clinical Centre Kragujevac, Kragujevac, Serbia
Prodanovic Nikola S.: Department of Alloartoplastic Surgery, Clinic for Orthopedics and Traumatology, University Clinical Center Kragujevac, 34000 Kragujevac, Serbia
Mijailovic Sara S.: Department of Medical Statistics and Informatics, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Knezevic Sanja M.: Department of Pediatrics, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Vuletic Biljana P.: Department of Pediatrics, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Stojkovic Andjelka K.: Department of Pediatrics, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Savic Dragana M.: Neonatal Intensive Care Unit, Center for Neonatology, Pediatric Clinic, University Clinical Centre Kragujevac, Kragujevac, Serbia
Prodanovic Tijana V.: Neonatal Intensive Care Unit, Center for Neonatology, Pediatric Clinic, University Clinical Centre Kragujevac, Kragujevac, Serbia
Stanojevic Marina M.: Department of Neonatology, Clinic for Gynecology and Obstetrics, University Clinical Centre Kragujevac, Kragujevac, Serbia
Simovic Aleksandra M.: Neonatal Intensive Care Unit, Center for Neonatology, Pediatric Clinic, University Clinical Centre Kragujevac, Kragujevac, Serbia

DOI: https://doi.org/10.1515/med-2022-0522
Journal volume & issue: Vol. 17, no. 1
pp. 1275 – 1281

Abstract

Read online

This study aimed to provide additional information on the influence of perinatal factors on fecal (f)-calprotectin values in preterm infants. Calprotectin was determined from the first spontaneous stool (analyzed on the Alegria device by using the enzyme-linked immunosorbent assay [ELISA] method) obtained from neonates at a mean age of 3.41 ± 2.44 days of life. We analyzed 114 subjects who had a body weight of 1847.67 ± 418.6 g and were born at a gestational age of 32.6 ± 2.43 weeks, without intestinal and other congenital anomalies or any diseases other than those related to premature birth. The values of f-calprotectin are in a positive correlation with female subjects, intrauterine growth restriction, significant ductus arteriosus, enteral feeding intolerance, postnatal prolonged use of broad-spectrum antibiotics, and values of bicarbonates (analyzed in a sample of capillary arterial blood). Measurement of f-calprotectin in the first 7 days after birth can help to early detect the intestinal distress or early staging of necrotizing enterocolitis in premature infants.

Published in Open Medicine

ISSN: 2391-5463 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Medicine
Website: https://www.degruyter.com/journal/key/med/html

About the journal

Abstract

Keywords