Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease

Ju Youn Lee; Seung Hoon Han; Min Hee Park; Bosung Baek; Im-Sook Song; Min-Koo Choi; Yoh Takuwa; Hoon Ryu; Seung Hyun Kim; Xingxuan He; Edward H. Schuchman; Jae-Sung Bae; Hee Kyung Jin

doi:10.1038/s41467-018-03674-2

Nature Communications (Apr 2018)

Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease

Ju Youn Lee,
Seung Hoon Han,
Min Hee Park,
Bosung Baek,
Im-Sook Song,
Min-Koo Choi,
Yoh Takuwa,
Hoon Ryu,
Seung Hyun Kim,
Xingxuan He,
Edward H. Schuchman,
Jae-Sung Bae,
Hee Kyung Jin

Affiliations

Ju Youn Lee: Stem Cell Neuroplasticity Research Group, Kyungpook National University
Seung Hoon Han: Stem Cell Neuroplasticity Research Group, Kyungpook National University
Min Hee Park: Stem Cell Neuroplasticity Research Group, Kyungpook National University
Bosung Baek: Stem Cell Neuroplasticity Research Group, Kyungpook National University
Im-Sook Song: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University
Min-Koo Choi: College of Pharmacy, Dankook University
Yoh Takuwa: Department of Physiology, Kanazawa University School of Medicine
Hoon Ryu: VA Boston Healthcare System, Department of Neurology and Boston University Alzheimer’s Disease Centre, Boston University School of Medicine
Seung Hyun Kim: Department of Neurology, Hanyang University College of Medicine
Xingxuan He: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
Edward H. Schuchman: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
Jae-Sung Bae: Stem Cell Neuroplasticity Research Group, Kyungpook National University
Hee Kyung Jin: Stem Cell Neuroplasticity Research Group, Kyungpook National University

DOI: https://doi.org/10.1038/s41467-018-03674-2
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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Sphingosine kinase (SphK) converts sphingosine into lipids, and is implicated in inflammation. Here the authors show that SphK1 functions as an acetyltransferase, regulates microglial phagocytosis and is reduced in a model of Alzheimer’s Disease, such that its restoration ameliorates pathology

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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