An Integrated Profiling of Liver Metabolome and Transcriptome of Pigs Fed Diets with Different Starch Sources

Miao Yu; Zhenming Li; Yiyan Cui; Ting Rong; Zhimei Tian; Dun Deng; Zhichang Liu; Ruiyang Zhang; Xianyong Ma

doi:10.3390/ani14223192

Animals (Nov 2024)

An Integrated Profiling of Liver Metabolome and Transcriptome of Pigs Fed Diets with Different Starch Sources

Miao Yu,
Zhenming Li,
Yiyan Cui,
Ting Rong,
Zhimei Tian,
Dun Deng,
Zhichang Liu,
Ruiyang Zhang,
Xianyong Ma

Affiliations

Miao Yu: Institute of Animal Science, Guangdong Academy of Agricultural Sciences, State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture, Guangdong Public Laboratory of Animal Breeding and Nutrition, Guangdong En-gineering Technology Research Center of animal Meat quality and Safety Control and Evaluation, Guangzhou 510640, China
Zhenming Li: Institute of Animal Science, Guangdong Academy of Agricultural Sciences, State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture, Guangdong Public Laboratory of Animal Breeding and Nutrition, Guangdong En-gineering Technology Research Center of animal Meat quality and Safety Control and Evaluation, Guangzhou 510640, China
Yiyan Cui: Institute of Animal Science, Guangdong Academy of Agricultural Sciences, State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture, Guangdong Public Laboratory of Animal Breeding and Nutrition, Guangdong En-gineering Technology Research Center of animal Meat quality and Safety Control and Evaluation, Guangzhou 510640, China
Ting Rong: Institute of Animal Science, Guangdong Academy of Agricultural Sciences, State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture, Guangdong Public Laboratory of Animal Breeding and Nutrition, Guangdong En-gineering Technology Research Center of animal Meat quality and Safety Control and Evaluation, Guangzhou 510640, China
Zhimei Tian: Institute of Animal Science, Guangdong Academy of Agricultural Sciences, State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture, Guangdong Public Laboratory of Animal Breeding and Nutrition, Guangdong En-gineering Technology Research Center of animal Meat quality and Safety Control and Evaluation, Guangzhou 510640, China
Dun Deng: Institute of Animal Science, Guangdong Academy of Agricultural Sciences, State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture, Guangdong Public Laboratory of Animal Breeding and Nutrition, Guangdong En-gineering Technology Research Center of animal Meat quality and Safety Control and Evaluation, Guangzhou 510640, China
Zhichang Liu: Institute of Animal Science, Guangdong Academy of Agricultural Sciences, State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture, Guangdong Public Laboratory of Animal Breeding and Nutrition, Guangdong En-gineering Technology Research Center of animal Meat quality and Safety Control and Evaluation, Guangzhou 510640, China
Ruiyang Zhang: College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China
Xianyong Ma: Institute of Animal Science, Guangdong Academy of Agricultural Sciences, State Key Laboratory of Swine and Poultry Breeding Industry, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture, Guangdong Public Laboratory of Animal Breeding and Nutrition, Guangdong En-gineering Technology Research Center of animal Meat quality and Safety Control and Evaluation, Guangzhou 510640, China

DOI: https://doi.org/10.3390/ani14223192
Journal volume & issue: Vol. 14, no. 22
p. 3192

Abstract

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Diets containing higher-amylose-content starches were proved to have some beneficial effects on monogastric animals, such as promoting the proliferation of intestinal probiotics. However, current research on the effects of diets with different starch sources on animals at the extraintestinal level is still very limited. We hypothesized that diets with different starch sources may affect lipid-related gene expression and metabolism in the liver of pigs. This study aimed to use adult pig models to evaluate the effects of diets with different starch sources (tapioca starch, TS; pea starch, PS) on the liver gene expressions and metabolism. In total, 48 growing pigs were randomly assigned to the TS and PS diets with 8 replicate pens/group and 3 pigs per pen. On day 44 of the experiment, liver samples were collected for metabolome and transcriptome analysis. Metabolome data suggested that different starch sources affected (p p p p p p p < 0.05) with liver gene expressions and metabolites. In summary, these findings suggest that diets containing higher amylose starches improved the lipid degradation and the unsaturated fatty acid levels in pig livers, and thus can generate some potential beneficial effects (such as anti-inflammatory and antioxidant) on pig health.

Published in Animals

ISSN: 2076-2615 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Agriculture: Animal culture: Veterinary medicine; Science: Zoology
Website: http://www.mdpi.com/journal/animals/

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