The cell adhesion molecule Fasciclin2 regulates brush border length and organization in Drosophila renal tubules

Kenneth A. Halberg; Stephanie M. Rainey; Iben R. Veland; Helen Neuert; Anthony J. Dornan; Christian Klämbt; Shireen-Anne Davies; Julian A. T. Dow

doi:10.1038/ncomms11266

Nature Communications (Apr 2016)

The cell adhesion molecule Fasciclin2 regulates brush border length and organization in Drosophila renal tubules

Kenneth A. Halberg,
Stephanie M. Rainey,
Iben R. Veland,
Helen Neuert,
Anthony J. Dornan,
Christian Klämbt,
Shireen-Anne Davies,
Julian A. T. Dow

Affiliations

Kenneth A. Halberg: Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Davidson Building Room 324, Glasgow G12 8QQ, UK
Stephanie M. Rainey: Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Davidson Building Room 324, Glasgow G12 8QQ, UK
Iben R. Veland: Cancer Research UK | Beatson Institute, Garscube Estate
Helen Neuert: Institut für Neuro- und Verhaltensbiologie, Universität Münster
Anthony J. Dornan: Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Davidson Building Room 324, Glasgow G12 8QQ, UK
Christian Klämbt: Institut für Neuro- und Verhaltensbiologie, Universität Münster
Shireen-Anne Davies: Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Davidson Building Room 324, Glasgow G12 8QQ, UK
Julian A. T. Dow: Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Davidson Building Room 324, Glasgow G12 8QQ, UK

DOI: https://doi.org/10.1038/ncomms11266
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 10

Abstract

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In Drosophila, Fasciclin 2 (Fas2) has been mainly studied in the nervous system, yet this adhesion protein is more abundant in the adult renal tubule. Here the authors show that Fas2 is essential for brush border maintenance in renal tubules through regulation of microvilli length and organization.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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