Nature Communications (Jan 2023)
CD26-negative and CD26-positive tissue-resident fibroblasts contribute to functionally distinct CAF subpopulations in breast cancer
- Julia M. Houthuijzen,
- Roebi de Bruijn,
- Eline van der Burg,
- Anne Paulien Drenth,
- Ellen Wientjens,
- Tamara Filipovic,
- Esme Bullock,
- Chiara S. Brambillasca,
- Emilia M. Pulver,
- Marja Nieuwland,
- Iris de Rink,
- Frank van Diepen,
- Sjoerd Klarenbeek,
- Ron Kerkhoven,
- Valerie G. Brunton,
- Colinda L.G.J. Scheele,
- Mirjam C. Boelens,
- Jos Jonkers
Affiliations
- Julia M. Houthuijzen
- Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute
- Roebi de Bruijn
- Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute
- Eline van der Burg
- Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute
- Anne Paulien Drenth
- Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute
- Ellen Wientjens
- Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute
- Tamara Filipovic
- Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute
- Esme Bullock
- Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
- Chiara S. Brambillasca
- Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute
- Emilia M. Pulver
- Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute
- Marja Nieuwland
- Genomics Core Facility, The Netherlands Cancer Institute
- Iris de Rink
- Genomics Core Facility, The Netherlands Cancer Institute
- Frank van Diepen
- Flow Cytometry Facility, The Netherlands Cancer Institute
- Sjoerd Klarenbeek
- Experimental Animal Pathology Facility, The Netherlands Cancer Institute
- Ron Kerkhoven
- Genomics Core Facility, The Netherlands Cancer Institute
- Valerie G. Brunton
- Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh
- Colinda L.G.J. Scheele
- Laboratory for Intravital Imaging and Dynamics of Tumor Progression, VIB Center for Cancer Biology, KU Leuven
- Mirjam C. Boelens
- Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute
- Jos Jonkers
- Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute
- DOI
- https://doi.org/10.1038/s41467-023-35793-w
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 21
Abstract
The origin of cancer-associated fibroblasts (CAFs) in cancer remains to be identified. Here, single-cell transcriptomics, in vivo and in vitro studies suggest that CD26+ and CD26- normal fibroblasts transform into distinct CAF subpopulations in mouse models of breast cancer.
