Cloaking nanoparticles with protein corona shield for targeted drug delivery

Jun Yong Oh; Han Sol Kim; L. Palanikumar; Eun Min Go; Batakrishna Jana; Soo Ah Park; Ho Young Kim; Kibeom Kim; Jeong Kon Seo; Sang Kyu Kwak; Chaekyu Kim; Sebyung Kang; Ja-Hyoung Ryu

doi:10.1038/s41467-018-06979-4

Nature Communications (Oct 2018)

Cloaking nanoparticles with protein corona shield for targeted drug delivery

Jun Yong Oh,
Han Sol Kim,
L. Palanikumar,
Eun Min Go,
Batakrishna Jana,
Soo Ah Park,
Ho Young Kim,
Kibeom Kim,
Jeong Kon Seo,
Sang Kyu Kwak,
Chaekyu Kim,
Sebyung Kang,
Ja-Hyoung Ryu

Affiliations

Jun Yong Oh: Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST)
Han Sol Kim: Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST)
L. Palanikumar: Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST)
Eun Min Go: Department of Energy Engineering, School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST)
Batakrishna Jana: Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST)
Soo Ah Park: In Vivo Research Center, UNIST, Central Research Facilities, Ulsan National Institute of Science and Technology (UNIST)
Ho Young Kim: Department of Energy Engineering, School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST)
Kibeom Kim: Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST)
Jeong Kon Seo: Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST)
Sang Kyu Kwak: Department of Energy Engineering, School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST)
Chaekyu Kim: Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST)
Sebyung Kang: Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST)
Ja-Hyoung Ryu: Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST)

DOI: https://doi.org/10.1038/s41467-018-06979-4
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 9

Abstract

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The efficacy of nanoparticles can be significantly inhibited by serum proteins binding to them. Here, the author developed a supramolecularly constructed protein corona on nanoparticles, which minimises interactions with serum proteins to prevent the clearance of these particles by macrophages.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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