Lineage dynamics of murine pancreatic development at single-cell resolution

Lauren E. Byrnes; Daniel M. Wong; Meena Subramaniam; Nathaniel P. Meyer; Caroline L. Gilchrist; Sarah M. Knox; Aaron D. Tward; Chun J. Ye; Julie B. Sneddon

doi:10.1038/s41467-018-06176-3

Nature Communications (Sep 2018)

Lineage dynamics of murine pancreatic development at single-cell resolution

Lauren E. Byrnes,
Daniel M. Wong,
Meena Subramaniam,
Nathaniel P. Meyer,
Caroline L. Gilchrist,
Sarah M. Knox,
Aaron D. Tward,
Chun J. Ye,
Julie B. Sneddon

Affiliations

Lauren E. Byrnes: Diabetes Center, University of California, San Francisco
Daniel M. Wong: Diabetes Center, University of California, San Francisco
Meena Subramaniam: Institute for Human Genetics, University of California, San Francisco
Nathaniel P. Meyer: Diabetes Center, University of California, San Francisco
Caroline L. Gilchrist: Diabetes Center, University of California, San Francisco
Sarah M. Knox: Department of Cell and Tissue Biology, University of California
Aaron D. Tward: Department of Otolaryngology-Head and Neck Surgery, University of California
Chun J. Ye: Institute for Human Genetics, University of California, San Francisco
Julie B. Sneddon: Diabetes Center, University of California, San Francisco

DOI: https://doi.org/10.1038/s41467-018-06176-3
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 17

Abstract

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Coordinated proliferation and differentiation of diverse cell populations drive pancreatic epithelial and mesenchymal development. Here, the authors profile cell type dynamics in the developing mouse pancreas using single-cell RNA sequencing, identifying mesenchymal subtypes and undescribed endocrine progenitors.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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