Features of the immune disbalance during various clinico-pathogenetic variants of acute progressive pulmonary tuberculosis

Abstract

In article the data, concerning features of cellular composition, proliferative activity and cytokines production of peripheral blood lymphocytes is presented in patients with various clinico-pathogenetic variants of pulmonary tuberculosis: drag-sensitive and drug-resistant infiltrative, disseminated, fibrous-cavernous. It is established that the extensive destructive tuberculosis without dependence from the clinical form of disease is accompanied by the expressed insufficiency of the cellular-mediated mechanisms of immunological resistance both to drag-sensitive, and to drug-resistant M. tuberculosis against quantitative prevalence of B-lymphocytes and intensity of their functional activity.

Keywords

• туберкулез легких
• иммунитет
• лимфоциты
• цитокины