Nature Communications (May 2021)
Analysis of diverse eukaryotes suggests the existence of an ancestral mitochondrial apparatus derived from the bacterial type II secretion system
- Lenka Horváthová,
- Vojtěch Žárský,
- Tomáš Pánek,
- Romain Derelle,
- Jan Pyrih,
- Alžběta Motyčková,
- Veronika Klápšťová,
- Martina Vinopalová,
- Lenka Marková,
- Luboš Voleman,
- Vladimír Klimeš,
- Markéta Petrů,
- Zuzana Vaitová,
- Ivan Čepička,
- Klára Hryzáková,
- Karel Harant,
- Michael W. Gray,
- Mohamed Chami,
- Ingrid Guilvout,
- Olivera Francetic,
- B. Franz Lang,
- Čestmír Vlček,
- Anastasios D. Tsaousis,
- Marek Eliáš,
- Pavel Doležal
Affiliations
- Lenka Horváthová
- Faculty of Science, Department of Parasitology, Charles University, BIOCEV
- Vojtěch Žárský
- Faculty of Science, Department of Parasitology, Charles University, BIOCEV
- Tomáš Pánek
- Faculty of Science, Department of Biology and Ecology, University of Ostrava
- Romain Derelle
- School of Biosciences, University of Birmingham
- Jan Pyrih
- Laboratory of Molecular & Evolutionary Parasitology, RAPID group, School of Biosciences, University of Kent
- Alžběta Motyčková
- Faculty of Science, Department of Parasitology, Charles University, BIOCEV
- Veronika Klápšťová
- Faculty of Science, Department of Parasitology, Charles University, BIOCEV
- Martina Vinopalová
- Faculty of Science, Department of Parasitology, Charles University, BIOCEV
- Lenka Marková
- Faculty of Science, Department of Parasitology, Charles University, BIOCEV
- Luboš Voleman
- Faculty of Science, Department of Parasitology, Charles University, BIOCEV
- Vladimír Klimeš
- Faculty of Science, Department of Biology and Ecology, University of Ostrava
- Markéta Petrů
- Faculty of Science, Department of Parasitology, Charles University, BIOCEV
- Zuzana Vaitová
- Faculty of Science, Department of Parasitology, Charles University, BIOCEV
- Ivan Čepička
- Faculty of Science, Department of Zoology, Charles University
- Klára Hryzáková
- Faculty of Science, Department of Genetics and Microbiology, Charles University
- Karel Harant
- Faculty of Science, Proteomic core facility, Charles University, BIOCEV
- Michael W. Gray
- Department of Biochemistry and Molecular Biology and Centre for Comparative Genomics and Evolutionary Bioinformatics, Dalhousie University
- Mohamed Chami
- Center for Cellular Imaging and NanoAnalytics, University of Basel
- Ingrid Guilvout
- Biochemistry of Macromolecular Interactions Unit, Department of Structural Biology and Chemistry, Institut Pasteur, CNRS UMR3528
- Olivera Francetic
- Biochemistry of Macromolecular Interactions Unit, Department of Structural Biology and Chemistry, Institut Pasteur, CNRS UMR3528
- B. Franz Lang
- Robert Cedergren Centre for Bioinformatics and Genomics, Département de Biochimie, Université de Montréal
- Čestmír Vlček
- Institute of Molecular Genetics, Czech Academy of Sciences
- Anastasios D. Tsaousis
- Laboratory of Molecular & Evolutionary Parasitology, RAPID group, School of Biosciences, University of Kent
- Marek Eliáš
- Faculty of Science, Department of Biology and Ecology, University of Ostrava
- Pavel Doležal
- Faculty of Science, Department of Parasitology, Charles University, BIOCEV
- DOI
- https://doi.org/10.1038/s41467-021-23046-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
Bacteria use the type 2 secretion system to secrete enzymes and toxins across the outer membrane to the environment. Here the authors analyse the T2SS pathway in three protist lineages and suggest that the early mitochondrion may have been capable of secreting proteins into the cytosol.
