Is there a relationship between rosacea with gut dysbiosis?

Abstract

Background: Rosacea is a common chronic inflammatory dermatosis that affects about 10% of the population. Although various environmental stimulants and endogenous factors have been shown to stimulate the innate immune response and abnormal neurovascular signaling in the etiology, the variety of clinical forms leads to a poor understanding of the pathophysiology of rosacea. Objectives: In this study, we aimed to determine the relationship between rosacea disease and the intestinal microbiome. Methods: For this purpose, 20 patients with clinical diagnosis of rosacea in the Education and Research Hospital of Sakarya University and 10 healthy volunteers with age and sex matched to the control group were included. 16s ribosomal RNA sequence and metagenomic analyses were performed from fecal samples. Results: We determined the relationships between various changes in the rosacea clinic and intestinal microbiome. According to the results of metagenomic DNA analysis in rosacea patients according to healthy volunteers, Lachnospira, Lachnoclostridium, Roseburia, and Roseburia intestinalis were found to be higher and Coriobacteriaceae, Ruminococcaceae, Butyricimonas virosa, and Clostridiales bacteria were found to be higher. Conclusion: These differences were thought to be related to indirect dysbiotic pathways with rosacea clinic. Since only one study examining the relationship between rosacea and intestinal microbiome can be reached in the literature, it is needed to have more and more sampling studies in order to make sense of the microorganisms that stand out.

Keywords

• ords: 16s ribosomal rna
• microbiome
• next-generation sequencing
• rosacea