Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation

Chun-Ping Cui; Yuan Zhang; Chanjuan Wang; Fang Yuan; Hongchang Li; Yuying Yao; Yuhan Chen; Chunnan Li; Wenyi Wei; Cui Hua Liu; Fuchu He; Yan Liu; Lingqiang Zhang

doi:10.1038/s41467-018-07025-z

Nature Communications (Nov 2018)

Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation

Chun-Ping Cui,
Yuan Zhang,
Chanjuan Wang,
Fang Yuan,
Hongchang Li,
Yuying Yao,
Yuhan Chen,
Chunnan Li,
Wenyi Wei,
Cui Hua Liu,
Fuchu He,
Yan Liu,
Lingqiang Zhang

Affiliations

Chun-Ping Cui: State Key Laboratory of Proteomics, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics
Yuan Zhang: State Key Laboratory of Proteomics, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics
Chanjuan Wang: State Key Laboratory of Proteomics, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics
Fang Yuan: State Key Laboratory of Reproductive Medicine, Institute for Stem Cell and Neural Regeneration, School of Pharmacy, Nanjing Medical University
Hongchang Li: State Key Laboratory of Proteomics, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics
Yuying Yao: State Key Laboratory of Proteomics, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics
Yuhan Chen: State Key Laboratory of Proteomics, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics
Chunnan Li: State Key Laboratory of Proteomics, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics
Wenyi Wei: Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
Cui Hua Liu: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Fuchu He: State Key Laboratory of Proteomics, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics
Yan Liu: State Key Laboratory of Reproductive Medicine, Institute for Stem Cell and Neural Regeneration, School of Pharmacy, Nanjing Medical University
Lingqiang Zhang: State Key Laboratory of Proteomics, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics

DOI: https://doi.org/10.1038/s41467-018-07025-z
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

Read online

Sox2 regulates pluripotency in neural progenitor cells (NPC) but how protein stability affects this is unclear. Here, the authors identify changes in ubiquitylation of Sox2 (by CUL4A-DET1-COP1 ligase and OTUD7B deubiquitylase) as controlling protein stability and so the differentiation state of NPCs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal