Leptomeningeal Carcinomatosis with Delayed Ocular Manifestations

Abstract

The most common presenting symptoms of leptomeningeal carcinomatosis (LC) are ocular manifestations with vision loss. There are multiple reports of undiagnosed LC causing sudden, complete, monocular vision loss as the presenting symptom; however, sudden bilateral vision loss 6 months following diagnosis has not been described. Any new ocular involvement or worsening of previous ocular symptoms warrants reimaging and prompt ophthalmology consultation, as this likely indicates disease progression. This report details a unique case of LC where a previously diagnosed patient developed sudden, complete, bilateral vision loss and multiple cranial nerve palsies with progression of LC on imaging.

Keywords

• leptomeningeal carcinomatosis
• ophthalmology
• cranial neuropathy
• optic neuropathy
• vision loss
• magnetic resonance imaging