Nature Communications (Feb 2019)

Targets of complement-fixing antibodies in protective immunity against malaria in children

  • Linda Reiling,
  • Michelle J. Boyle,
  • Michael T. White,
  • Danny W. Wilson,
  • Gaoqian Feng,
  • Rupert Weaver,
  • D. Herbert Opi,
  • Kristina E. M. Persson,
  • Jack S. Richards,
  • Peter M. Siba,
  • Freya J. I. Fowkes,
  • Eizo Takashima,
  • Takafumi Tsuboi,
  • Ivo Mueller,
  • James G. Beeson

DOI
https://doi.org/10.1038/s41467-019-08528-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

Read online

Antibodies against Plasmodium falciparum merozoites that fix complement can inhibit blood-stage replication. Here, Reiling et al. show that complement-fixing antibodies strongly correlate with protective immunity in children, identify the merozoite targets, and predict antigen combinations that should result in strong protection.