Child-parent associations of hematocrit in trios of Japanese adulthood confirmed by the random family method: The TMM BirThree Cohort Study

Abstract

Abstract To examine child-parent associations of HCT among Japanese adults and their parents. Factors associated with hematocrit (HCT) were analyzed in 3,574 sons and 7,203 daughters using Pearson’s correlation coefficient and Student’s t-test. Multiple linear regression analysis, adjusted by the factors identified by univariate analyses and by living with parents, was performed on 242 son-parent trios and 587 daughter-parent trios. When a child-parent association was observed in the multiple linear regression analysis, it was validated using the random family method (RFM). In univariate analyses, the son’s HCT was associated with age (correlation coefficient = –0.072), white blood cell (WBC) (0.19), alanine aminotransferase (ALT) (0.20), triglyceride (0.11), and estimated glomerular filtration rate (eGFR) (− 0.087). The daughter’s HCT was associated with WBC (0.014), ALT (0.18), and eGFR (− 0.17). In multiple linear regression analysis, the son’s HCT was associated with the son’s WBC (coefficient = 3.48 × 10–4), the son’s eGFR (0.031), the father’s HCT (0.11), and the mother’s HCT (0.17). RFM confirmed the association between the son’s and father’s HCT (p = 0.0070) and between the son’s and mother’s HCT (p = 0.0011). The daughter’s HCT was associated with WBC (2.6 × 10–4), ALT (0.037), and the mother’s HCT (0.14). RFM confirmed the association between the daughter’s and mother’s HCT (p = 0.00043). Child-parent association of HCT was confirmed between son-father, son–mother, and daughter-mother relationships, and differed depending on the sex of the child and the parents.

Keywords

• Bootstrap method
• Child-parent association
• Hematocrit
• Permutation method