Molecules (Dec 2024)

Asymmetric Synthesis of 2-Arylethylamines: A Metal-Free Review of the New Millennium

  • Alejandro Manchado,
  • Ángel García-González,
  • Carlos T. Nieto,
  • David Díez,
  • Narciso M. Garrido

DOI
https://doi.org/10.3390/molecules29235729
Journal volume & issue
Vol. 29, no. 23
p. 5729

Abstract

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2-Arylethylamines are presented in several natural bioactive compounds, as well as in nitrogen-containing drugs. Their ability to surpass the blood–brain barrier makes this family of compounds of especial interest in medicinal chemistry. Asymmetric methodologies towards the synthesis of 2-arylethylamine motives are of great interest due to the challenges they may present. Thus, a concise metal-free review presenting recent advances in the asymmetric synthesis of 2-arylethylamines is presented, covering last-millennium studies, considering different methodologies towards the aforementioned motif, including chiral induction, organocatalysis, organophotocatalysis and enzymatic catalysis.

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