A Concise Synthesis of Sacidumlignan B

Zhiyuan Zhuang; Zhenbiao Luo; Sichen Yao; Yawen Wang; Yu Peng

doi:10.3390/molecules27185775

Molecules (Sep 2022)

A Concise Synthesis of Sacidumlignan B

Zhiyuan Zhuang,
Zhenbiao Luo,
Sichen Yao,
Yawen Wang,
Yu Peng

Affiliations

Zhiyuan Zhuang: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China
Zhenbiao Luo: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China
Sichen Yao: Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China
Yawen Wang: Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China
Yu Peng: Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China

DOI: https://doi.org/10.3390/molecules27185775
Journal volume & issue: Vol. 27, no. 18
p. 5775

Abstract

Read online

A short synthesis of racemic Sacidumlignan B was achieved for the first time. The key steps included a formal reductive coupling between the diaryl ketone and the crotyl bromide, and the subsequent Friedel–Crafts cyclization, which led to an efficient construction of dihydronaphthalene skeleton in this 2,7′-cyclolignan natural product.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

About the journal

Abstract

Keywords