Journal of Hepatocellular Carcinoma (Dec 2022)

Advanced Hepatocellular Carcinoma in Adults Without Cirrhosis: A Single-Institution Retrospective Review

  • Altshuler E,
  • Richhart R,
  • Aryan M,
  • King W,
  • Pan K,
  • Mathavan A,
  • Mathavan A,
  • Rodriguez D,
  • Paudel B,
  • Northern N,
  • Ramnaraign B,
  • Sahin I,
  • Fabregas, JC

Journal volume & issue
Vol. Volume 9
pp. 1299 – 1307

Abstract

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Ellery Altshuler,1 Raymond Richhart,1 Mahmoud Aryan,2 William King,1 Kelsey Pan,1 Akash Mathavan,1 Akshay Mathavan,1 Diana Rodriguez,1 Bishal Paudel,1 Nathan Northern,1 Brian Ramnaraign,3 Ilyas Sahin,3 Jesus C Fabregas3 1Department of Internal Medicine, University of Florida College of Medicine, Gainesville, FL, USA; 2Department of Internal Medicine, University of Alabama Birmingham College of Medicine, Birmingham, AL, USA; 3Division of Hematology and Oncology, University of Florida College of Medicine, Gainesville, FL, USACorrespondence: Jesus C Fabregas, Department of Hematology and Oncology, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL, 32608, USA, Tel +1 305-389-6231, Email [email protected]: Although up to one in five cases of hepatocellular carcinoma (HCC) occurs in patients without cirrhosis, there is scarce literature characterizing non-cirrhotic HCC (NCHCC). Existing NCHCC research is primarily limited to surgical case series and there is a lack of data on unresectable NCHCC.Aim: The purpose of this retrospective review was to compare the characteristics of unresectable NCHCC and cirrhotic hepatocellular carcinoma (CHCC).Methods: A retrospective chart review of adult patients with unresectable HCC treated from 2007 to 2017 was performed at the University of Florida Shands Hospital. The data set was stratified into two cohorts: NCHCC and CHCC. Continuous variables were compared using Wilcoxon-Mann–Whitney tests and Kruskal–Wallis rank-sum tests. Categorical variables were compared using Pearson’s Chi-squared tests and Fisher’s exact tests. Overall survival was explored utilizing the Kaplan-Meier and log-rank method.Results: There were 1494 adult patients included in the final analysis, including 264 patients (17.7%) with NCHCC and 1230 patients (82.3%) with CHCC. Median age was 61.0 years old and median follow-up time was 30.2 months. NCHCC patients were older than CHCC patients (66.3 years vs 61.9 years; p < 0.0001). NHCC tumors were larger than CHCC tumors (7.92 ± 4.85 vs 4.38 ± 3.12 cm; p < 0.0001) and more likely to be associated with distant metastases (23.35% vs 15.91%; p = 0.0055). There was no difference in overall survival, with a median of 23.5 months in NCHCC and 22.4 months in CHCC (p = 0.9196).Conclusion: Our findings suggest that unresectable NCHCC and CHCC have unique characteristics but similar overall survival. To the best of our knowledge, this is the largest comparison of CHCC and NCHCC.Keywords: hepatocellular carcinoma, cirrhosis, non-cirrhotic

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